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. 2024 Sep 3:2024:8159993.
doi: 10.1155/2024/8159993. eCollection 2024.

Effect of Smoking on Seminal Plasma Vitamin B6 in Fertile and Subfertile Men

Shefa' Muneer Aljabali  1 , Saleem Ali Banihani  1
Affiliations

Effect of Smoking on Seminal Plasma Vitamin B6 in Fertile and Subfertile Men

Shefa' Muneer Aljabali et al. J Nutr Metab. .

Abstract

Despite extensive documentation of the negative consequences of smoking on a wide range of diseases and disorders, the direct effect of smoking on seminal plasma vitamin B6 (vitB6) concentration is not addressed yet. Here, we attempted to examine the influence of smoking on the levels of seminal plasma vitB6 in fertile and subfertile males. One hundred and ninety-five participants were categorized into two groups: fertile men (smokers (n = 32), nonsmokers (n = 43)) and subfertile men (smokers (n = 65), nonsmokers (n = 55)). According to the World Health Organization criteria, conventional semen analysis was performed for all subjects involved in the study. The concentration of vitB6 in semen samples was measured by high-performance liquid chromatography tandem-mass spectrometry. There was no significant difference in the mean seminal plasma concentrations of vitB6 in smokers versus nonsmokers in both fertile (p=0.5096) and subfertile (p=0.5224) groups. Besides, no significant correlations were observed between seminal plasma concentration of vitB6, duration of smoking, and men's age in all tested groups. In conclusion, these findings elucidate that smoking has no significant impact on the levels of seminal plasma vitB6 in both fertile and subfertile men.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Concentrations of seminal plasma vitB6 in fertile smokers (n = 32) compared to fertile nonsmokers (n = 43). Data are represented as mean ± standard error of the mean.
Figure 2
Figure 2
Concentrations of seminal plasma vitB6 in subfertile smokers (n = 65) compared to subfertile nonsmokers (n = 55). Data are represented as mean ± standard error of the mean.
Figure 3
Figure 3
Correlations between seminal plasma vitB6 concentrations in fertile men (a) (n = 75) and subfertile men (b) (n = 120) and duration of smoking.
Figure 4
Figure 4
Correlations between seminal plasma vitB6 concentrations in fertile men ((a) smokers (n = 32); (b) nonsmokers (n = 43)) and infertile men ((c) smokers (n = 65); (d) nonsmokers (n = 55)) versus men's age.
Figure 5
Figure 5
Possible mechanistic routes for the impact of vitB6 on semen quality in men.
See this image and copyright information in PMC

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