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Randomized Controlled Trial
. 2024 May 31;103(22):e38390.
doi: 10.1097/MD.0000000000038390.

Clinical observation of topical antipruritic spray acting on epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of dermatitis

Lei Fu  1 , Meijiao Li  1 , Peng Wang  1 , Lang Chen  1 , Jianqiu Huang  1 , Hui Zhang  2
Affiliations
Randomized Controlled Trial

Clinical observation of topical antipruritic spray acting on epidermal growth factor receptor tyrosine kinase inhibitor in the treatment of dermatitis

Lei Fu et al. Medicine (Baltimore). .

Abstract

To observe the efficacy of topical antipruritic spray (TAS) in the treatment of epidermal growth factor receptor (EGFR) tyrosine kinase-related rashes, and to evaluate its efficacy and safety. 120 malignant tumor patients with confirmed pathological diagnosis and rash after EGFR application were selected and randomly divided into an experimental group of 60 cases and a control group of 60 cases. The 2 groups were intervened with self-made antipruritic spray and erythromycin ointment for 14 consecutive days. To observe the changes in rash, itching degree, and quality of life index of skin diseases in both groups of patients before and after treatment. The decrease in the number of itching cases in the experimental group reached 53.84%, and after 7 weeks of intervention, the total effective rate of rash treatment in this group of patients (91.67%) was significantly better than that in the control group (36.67%); The symptoms of the dermatology life quality index (DLQI) scale in the experimental group patient table after intervention showed significant changes compared to before intervention. After statistical testing, there was a significant difference between the groups and outside the group (R < 0.05). And the comprehensive effect of the experimental patients with external spray after 14 weeks of intervention reached 93.16%. The self-made antipruritic spray has significant effect on improving EGFR rash and itching, and there is no obvious adverse reaction.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Rash grading of patients before and after treatment.
Figure 2.
Figure 2.
Pruritus symptoms of patients before and after treatment.
Figure 3.
Figure 3.
Improvement of patient condition before and after treatment.
Figure 4.
Figure 4.
Changes in serum factor expression levels before and after experimental intervention.
Figure 5.
Figure 5.
Satisfaction score of patients after treatment.
Figure 6.
Figure 6.
Survival statistics of follow-up patients.
See this image and copyright information in PMC

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