Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Oct;202(5):513-522.
doi: 10.1007/s00408-024-00740-z. Epub 2024 Sep 11.

Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors

Xi Zhu  1 , Leyuan Meng  2 , Liqin Xu  1 , Yun Hua  1 , Jian Feng  3
Affiliations
Review

Novel Therapeutic Target for ALI/ARDS: Forkhead Box Transcription Factors

Xi Zhu et al. Lung. 2024 Oct.

Abstract

ALI/ARDS can be a pulmonary manifestation of a systemic inflammatory response or a result of overexpression of the body's normal inflammatory response involving various effector cells, cytokines, and inflammatory mediators, which regulate the body's immune response through different signalling pathways. Forkhead box transcription factors are evolutionarily conserved transcription factors that play a crucial role in various cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Transcription factors control protein synthesis by regulating gene transcription levels, resulting in diverse biological outcomes. The Fox family plays a role in activating or inhibiting the expression of various molecules related to ALI/ARDS through phosphorylation, acetylation/deacetylation, and control of multiple signalling pathways. An in-depth analysis of the integrated Fox family's role in ALI/ARDS can aid in the development of potential diagnostic and therapeutic targets for the condition.

Keywords: Acute lung injury; Acute respiratory distress syndrome; Fox transcription factor; PI3K/AKT pathway.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

  • LUNG Year in Review: 2024.
    Dicpinigaitis PV. Dicpinigaitis PV. Lung. 2025 Jan 22;203(1):29. doi: 10.1007/s00408-025-00785-8. Lung. 2025. PMID: 39841240 No abstract available.
  • The Reparative Effect of FOXM1 in Pulmonary Disease.
    Chen T, Ni M, Wang H, Xue F, Jiang T, Wu X, Li C, Liang S, Hong L, Wu Q. Chen T, et al. Lung. 2024 Nov 27;203(1):1. doi: 10.1007/s00408-024-00773-4. Lung. 2024. PMID: 39601876 Review.

References

    1. Goatly G, Guidozzi N, Khan M (2019) Optimal ventilator strategies for trauma-related ARDS. J R Army Med Corps 165(3):193–197. https://doi.org/10.1136/jramc-2017-000889 - DOI - PubMed
    1. Aoyama H et al (2019) Assessment of therapeutic interventions and lung protective ventilation in patients with moderate to severe acute respiratory distress syndrome: a systematic review and network meta-analysis. JAMA Netw Open 2(7):e198116. https://doi.org/10.1001/jamanetworkopen.2019.8116 - DOI - PubMed - PMC
    1. O’Gara B, Talmor D (2018) Perioperative lung protective ventilation. BMJ 362:k3030. https://doi.org/10.1136/bmj.k3030 - DOI - PubMed - PMC
    1. Welker C et al (2022) 2021 acute respiratory distress syndrome update, with coronavirus disease 2019 focus. J Cardiothorac Vasc Anesth 36(4):1188–1195. https://doi.org/10.1053/j.jvca.2021.02.053 - DOI - PubMed
    1. Yang A et al (2021) Role of specialized pro-resolving lipid mediators in pulmonary inflammation diseases: mechanisms and development. Respir Res 22(1):204. https://doi.org/10.1186/s12931-021-01792-y - DOI - PubMed - PMC

Publication types

MeSH terms

Substances

LinkOut - more resources