Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 11;42(1):519.
doi: 10.1007/s00345-024-05190-z.

Nocturia and obstructive sleep apnea in spinal cord injured patients - a cohort study

C Lambert  1   2 , J Di Maria  3 , P Denys  2   4 , A Even  2   4 , A Welniarz  2 , S Hartley  3 , H Prigent  2   4 , A Leotard #  2   4 , Charles Joussain #  5   6
Affiliations

Nocturia and obstructive sleep apnea in spinal cord injured patients - a cohort study

C Lambert et al. World J Urol. .

Abstract

Purpose: To describe the prevalence of nocturia and obstructive sleep apnea (OSA) in a cohort of spinal cord injury (SCI) patients and to describe their association. Additionally, to assess clinical and urodynamic data explaining nocturia and to evaluate the effect of OSA management with continuous positive airway pressure (CPAP).

Method: Retrospective analysis of data from patients with SCI followed in a tertiary care rehabilitation center with a specialized sleep and neuro-urology units. All adult SCI patients who underwent urodynamic assessment before polysomnography (PSG) between 2015 and 2023 were eligible. Subjective (nocturia) and objective data (urodynamic data, polysomnography, CPAP built-in software) were collated from the Handisom database (database register no. 20200224113128) and the medical records of SCI patients. Statistical testing used Mann-Whitney test for non-parametric variables, Fisher's exact test for contingency analysis and the Spearman correlation test to assess correlations. A p-value < 0.05 was considered significant. Statistical analyses were performed using GraphPad Prism v9.

Results: 173 patients (131 males, 42 females) were included. The majority of patients were paraplegic (n = 111 (64,2%)) and had complete lesions (n = 75 (43,4%)). A total of 100 patients had nocturia (57,5%). The prevalence of OSA (Apnea Hypopnea Index (AHI) ≥ 15/h) in the studied population was 61,9%. No correlation was found between nocturia and OSA. A significant difference was observed between patients with and without nocturia in terms of the presence of neurogenic detrusor overactivity (p = 0,049), volume at the first detrusor contraction (p = 0,004) and the bladder functional capacity (p < 0,001).

Conclusion: Nocturia and OSA are highly prevalent in patients with SCI, but no statistical association was found between these two disorders. A prospective study focusing on nocturnal polyuria will be needed to assess the impact of OSA on lower urinary tract symptoms in SCI patients.

Keywords: Continuous positive airway pressure (CPAP); Nocturia; Obstructive sleep apnea syndrome (OSA); Spinal cord injury (SCI).

PubMed Disclaimer

References

    1. van Dijk L, Kooij DG, Schellevis FG et al (2004) Nocturia: impact on quality of life in a Dutch adult population. BJU Int 93:1001–1004. https://doi.org/10.1111/j.1464-410X.2004.04769.x - DOI - PubMed
    1. van Kerrebroeck P, Abrams P, Chaikin D et al (2002) The standardisation of terminology in nocturia: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:179–183. https://doi.org/10.1002/nau.10053 - DOI - PubMed
    1. Bosch JLHR, Weiss JP (2013) The prevalence and causes of nocturia. J Urol 189:S86–92. https://doi.org/10.1016/j.juro.2012.11.033 - DOI - PubMed
    1. Yu H-J, Chen F-Y, Huang P-C et al (2006) Impact of nocturia on symptom-specific quality of life among community-dwelling adults aged 40 years and older. Urology 67:713–718. https://doi.org/10.1016/j.urology.2005.10.054 - DOI - PubMed
    1. Ancoli-Israel S, Bliwise DL, Nørgaard JP (2011) The effect of nocturia on sleep. Sleep Med Rev 15:91–97. https://doi.org/10.1016/j.smrv.2010.03.002 - DOI - PubMed

LinkOut - more resources