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Multicenter Study
. 2025 Jul-Aug;40(4):345-355.
doi: 10.1097/JCN.0000000000001129. Epub 2024 Sep 11.

Association of Novel Ventricular Assist Device Self-report Measures With Overall Health-Related Quality of Life

Kathleen L Grady, James L Burns, Larry A Allen, Josef Stehlik, Jeffrey Teuteberg, Colleen K McIlvennan, James K Kirklin, David G Beiser, JoAnn Lindenfeld, Quin E Denfeld, Christopher S Lee, Michael Kiernan, David Cella, Liviu Klein, Mary Norine Walsh, Bernice Ruo, Eric Adler, Jonathan Rich, Duc Thinh Pham, Clyde Yancy, Catherine Murks, Katy Bedjeti, Elizabeth A Hahn
Multicenter Study

Association of Novel Ventricular Assist Device Self-report Measures With Overall Health-Related Quality of Life

Kathleen L Grady et al. J Cardiovasc Nurs. 2025 Jul-Aug.

Abstract

Background: Few study authors examined factors influencing health-related quality of life (HRQOL) early after left ventricular assist device (LVAD) implantation.

Objective: The purpose of this study was to determine whether 5 novel self-report measures and other variables were significantly associated with overall HRQOL at 3 months after LVAD surgery.

Methods: Patients were recruited between October 26, 2016, and February 29, 2020, from 12 US sites. Data were collected before LVAD implantation and at 3 months post LVAD implantation. Overall HRQOL measures included the Kansas City Cardiomyopathy Questionnaire-12 (KCCQ-12) overall summary score (OSS) and EuroQol 5-dimension- 3L visual analog scale. Potential factors associated with overall HRQOL included 5 novel self-report measures (Satisfaction with Treatment, Being Bothered by VAD Self-care and Limitations, VAD Team Communication, Self-efficacy regarding VAD Self-care, and Stigma), and demographic and clinical characteristics. Statistics included regression analyses.

Results: Of enrollees, 242 completed self-report measures at baseline, and 142 completed measures 3 months postoperatively. Patients were 55 ± 13 years old, with 21% female, 24% non-White, 39% high school or lower educated, and 47% destination therapy. Using the KCCQ-12 OSS, higher Satisfaction with Treatment was associated with a higher KCCQ-12 OSS; Being Bothered by VAD Self-care and Limitations, high school or lower education, chest incision pain, cardiac dysrhythmias within 3 postoperative months, and peripheral edema were associated with a worse KCCQ-12 OSS ( R2 = 0.524). Factors associated with a worse 3-month EuroQol 5-dimension-3L visual analog scale were female sex, adverse events within 3 months post implantation (cardiac dysrhythmias, bleeding, and venous thrombosis), and chest incision pain ( R2 = 0.229). No factors were associated with a higher EuroQol 5-dimension-3L visual analog scale score at 3 months.

Conclusions: Two novel measures, demographics, postimplantation adverse events, and symptoms were associated with post-LVAD KCCQ-12 OSS early after surgery.

Keywords: mechanical circulatory support; patient-reported outcomes; quality of life; ventricular assist device.

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References

    1. Grady KL, Naftel D, Stevenson L, et al. Overall quality of life improves to similar levels after mechanical circulatory support regardless of severity of heart failure before implantation. J Heart Lung Transplant . 2014;33(4):412–421.
    1. Grady KL, Naftel DC, Myers S, et al. Change in health-related quality of life from before to after destination therapy mechanical circulatory support is similar for older and younger patients: analyses from INTERMACS. J Heart Lung Transplant . 2015;34(2):213–221.
    1. Grady KL, Wissman S, Naftel DC, et al. Age and gender differences and factors related to change in health-related quality of life from before to 6 months after left ventricular assist device implantation: findings from Interagency Registry for Mechanically Assisted Circulatory Support. J Heart Lung Transplant . 2016;35(6):777–788.
    1. Bidwell JT, Lyons KS, Mudd JO, et al. Quality of life, depression, and anxiety in ventricular assist device therapy: longitudinal outcomes for patients and family caregivers. J Cardiovasc Nurs . 2017;32(5):455–463.
    1. Nassif ME, Spertus JA, Jones PG, et al. Changes in disease-specific versus generic health status measures after left ventricular assist device implantation. Insights from INTERMACS. J Heart Lung Transplant . 2017;36(11):1243–1249.

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