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. 1985;35(4):707-12.

Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics

K Geisen, V Hitzel, R Okomonopoulos, J Pünter, R Weyer, H D Summ
  • PMID: 3925960

Inhibition of 3H-glibenclamide binding to sulfonylurea receptors by oral antidiabetics

K Geisen et al. Arzneimittelforschung. 1985.

Abstract

Specific binding of 3H-glibenclamide (HB 419) is observed with membranes from rat cerebral cortex and rat beta-cell tumor. 3H-Glibenclamide binding is of high affinity, reversible, saturable, and can be displaced by oral antidiabetics of different structural types. Half maximal inhibition of binding correlates with the hypoglycemic action of the compounds.

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