A vision to the future: value-based laboratory medicine

Mario Plebani¹, Janne Cadamuro², Pieter Vermeersch³, Snežana Jovičić⁴, Tomris Ozben^{5

6}, Tommaso Trenti⁷, Brian McMillan⁸, Christopher R Lowe⁹, Jochen Lennerz¹⁰, Elizabeth Macintyre¹¹, Carlo Gabelli¹², Sverre Sandberg¹³, Andrea Padoan^{14

15}, Joesph R Wiencek¹⁶, Giuseppe Banfi^{17

18}, Ira M Lubin¹⁹, Matthias Orth^{20

21}, Anna Carobene²², Tomáš Zima²³, Christa M Cobbaert^{24

25}, Ron H N van Schaik²⁶, Giuseppe Lippi²⁷

Affiliations

¹ Department of Laboratory Medicine, University of Padova, Padova, Italy.
² Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
³ Clinical Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium.
⁴ Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
⁵ Medical Faculty, Department of Medical Biochemistry, Akdeniz University, Antalya, Türkiye.
⁶ Medical Faculty, Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy.
⁷ Bianalisi Group Monza, Roma, Italy.
⁸ Centre of Primary Care and Health Services Research, University of Manchester, Manchester, UK.
⁹ Trinity College, University of Cambridge, Cambridge, UK.
¹⁰ BostonGene, Waltham, MA, USA.
¹¹ Onco-Hematology Laboratory, Necker Hospital and Université Paris Cité, Paris, France.
¹² Research Centre for Brain Aging (CRIC), University Hospital of Padua, Padova, Italy.
¹³ Noklus, Haraldsplass Deaconess Hospital, Bergen, Norway.
¹⁴ Department of Medicine, University of Padova, Padova, Italy.
¹⁵ Laboratory Medicine Unit, University-Hospital of Padova, Padova, Italy.
¹⁶ Department of Pathology, Microbiology, and Immunology, Vanderbilt School of Medicine, Nashville, TN, USA.
¹⁷ IRCCS Galeazzi Sant'Ambrogio, Milan, Italy.
¹⁸ University Vita e Salute San Raffaele, Milan, Italy.
¹⁹ Division of Laboratory Systems, Center for Laboratory Systems and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
²⁰ Medical Faculty of Mannheim, Vinzenz von Paul Kliniken gGmbH, Stuttgart, Germany.
²¹ Heidelberg University, Heidelberg, Germany.
²² Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
²³ Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
²⁴ Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.
²⁵ EFLM Committee on European Regulatory Affairs and EFLM Liaison to BioMed Alliance in Europe, Brussels, Belgium.
²⁶ Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
²⁷ Section of Clinical Biochemistry, University of Verona, Verona, Italy.

PMID: 39259894
DOI: 10.1515/cclm-2024-1022

Free article

A vision to the future: value-based laboratory medicine

Mario Plebani et al. Clin Chem Lab Med. 2024.

Free article

. 2024 Sep 13;62(12):2373-2387.

doi: 10.1515/cclm-2024-1022. Print 2024 Nov 26.

Authors

Affiliations

¹ Department of Laboratory Medicine, University of Padova, Padova, Italy.
² Department of Laboratory Medicine, Paracelsus Medical University, Salzburg, Austria.
³ Clinical Department of Laboratory Medicine, UZ Leuven, Leuven, Belgium.
⁴ Department of Medical Biochemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
⁵ Medical Faculty, Department of Medical Biochemistry, Akdeniz University, Antalya, Türkiye.
⁶ Medical Faculty, Clinical and Experimental Medicine, University of Modena and Reggio Emilia, Modena, Italy.
⁷ Bianalisi Group Monza, Roma, Italy.
⁸ Centre of Primary Care and Health Services Research, University of Manchester, Manchester, UK.
⁹ Trinity College, University of Cambridge, Cambridge, UK.
¹⁰ BostonGene, Waltham, MA, USA.
¹¹ Onco-Hematology Laboratory, Necker Hospital and Université Paris Cité, Paris, France.
¹² Research Centre for Brain Aging (CRIC), University Hospital of Padua, Padova, Italy.
¹³ Noklus, Haraldsplass Deaconess Hospital, Bergen, Norway.
¹⁴ Department of Medicine, University of Padova, Padova, Italy.
¹⁵ Laboratory Medicine Unit, University-Hospital of Padova, Padova, Italy.
¹⁶ Department of Pathology, Microbiology, and Immunology, Vanderbilt School of Medicine, Nashville, TN, USA.
¹⁷ IRCCS Galeazzi Sant'Ambrogio, Milan, Italy.
¹⁸ University Vita e Salute San Raffaele, Milan, Italy.
¹⁹ Division of Laboratory Systems, Center for Laboratory Systems and Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
²⁰ Medical Faculty of Mannheim, Vinzenz von Paul Kliniken gGmbH, Stuttgart, Germany.
²¹ Heidelberg University, Heidelberg, Germany.
²² Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
²³ Institute of Medical Biochemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
²⁴ Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, The Netherlands.
²⁵ EFLM Committee on European Regulatory Affairs and EFLM Liaison to BioMed Alliance in Europe, Brussels, Belgium.
²⁶ Department of Clinical Chemistry, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
²⁷ Section of Clinical Biochemistry, University of Verona, Verona, Italy.

PMID: 39259894
DOI: 10.1515/cclm-2024-1022

Abstract

The ultimate goal of value-based laboratory medicine is maximizing the effectiveness of laboratory tests in improving patient outcomes, optimizing resources and minimizing unnecessary costs. This approach abandons the oversimplified notion of test volume and cost, in favor of emphasizing the clinical utility and quality of diagnostic tests in the clinical decision-making. Several key elements characterize value-based laboratory medicine, which can be summarized in some basic concepts, such as organization of in vitro diagnostics (including appropriateness, integrated diagnostics, networking, remote patient monitoring, disruptive innovations), translation of laboratory data into clinical information and measurable outcomes, sustainability, reimbursement, ethics (e.g., patient empowerment and safety, data protection, analysis of big data, scientific publishing). Education and training are also crucial, along with considerations for the future of the profession, which will be largely influenced by advances in automation, information technology, artificial intelligence, and regulations concerning in vitro diagnostics. This collective opinion paper, composed of summaries from presentations given at the two-day European Federation of Laboratory Medicine (EFLM) Strategic Conference "A vision to the future: value-based laboratory medicine" (Padova, Italy; September 23-24, 2024), aims to provide a comprehensive overview of value-based laboratory medicine, projecting the profession into a more clinically effective and sustainable future.

Keywords: home testing; laboratory medicine; technology; value.

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References

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1. Keppel, M, Kolbitsch, T, Hoppe, UC, Auer, S, Felder, TK, Oberkofler, H, et al.. The clinically effective use of cardiac markers by restructuring laboratory profiles at Cardiology wards. Clin Chem Lab Med 2020;58:1565–71. https://doi.org/10.1515/cclm-2019-1229 . - DOI

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A vision to the future: value-based laboratory medicine

Affiliations

A vision to the future: value-based laboratory medicine

Authors

Affiliations

Abstract

References

MeSH terms

LinkOut - more resources

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