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Comment
. 2024 Sep 10;57(9):2000-2002.
doi: 10.1016/j.immuni.2024.08.006.

Microglia bridge brain activity and blood pressure

Yanxia Rao  1 , Bo Peng  2
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Microglia bridge brain activity and blood pressure

Yanxia Rao et al. Immunity. .
Free article

Abstract

Our brain is not an immune-privileged island isolated from peripheries, but how non-neuronal brain cells interact with the peripheral system is not well understood. Wei et al. report that microglia in the hypothalamic paraventricular nucleus (PVN) with unique vasculature can detect ATP derived from hemodynamic disturbance. These microglia in the PVN regulate the response to hypertension via ATP-P2Y12-C/EBPβ signaling.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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