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Comment
. 2024 Sep 10;57(9):2002-2004.
doi: 10.1016/j.immuni.2024.08.012.

Neighbor's feedback helps macrophages learn tolerance in the gut

Giuseppe Giuliani  1 , Jayajit Das  2
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Neighbor's feedback helps macrophages learn tolerance in the gut

Giuseppe Giuliani et al. Immunity. .
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Abstract

Intestinal macrophages play a key role in regulating immune tolerance in the gut. In this issue of Immunity, Mertens et al. uncover a mechanism for the establishment of memory in macrophage tolerance in the gut involving a bistable metabolic switch in macrophages and an intercellular positive feedback between macrophages and intestinal epithelial cells (IECs).

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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