Predictive Value of MiR-192-5p for Complications after Caesarean Section with Scarred Uterus

Abstract

The risk of a second caesarean section with scarred uterus has attracted attention, and this study aimed to find a molecular marker to assist physicians in prenatal screening to better predict postpartum complications. Serum miR-192-5p expression was determined by qRT-PCR and 145 subjects were divided into low expression group (76) and high expression group (69) based on the miR-192-5p levels. The Receiver Operating Characteristic curve (ROC) was plotted with pelvic floor dysfunction (PFD) score, vaginal microecological environment status, and the occurrence of serious complications occurred as dependent variables. miR-192-5p expression was the test variable. Significant differences were found between the high and low MiR-192-5p expression groups in postpartum class I, class II muscle fiber strength, PFD score (p < 0.01), postpartum vaginal leukocyte esterase (p < 0.001), sialyl glycosidase (p = 0.010), acetylglucosaminidase (p = 0.024), and severe complications (p = 0.001). The ROC for predicting PFD showed an AUC of 0.861. The ROC for predicting vaginal microecological environment showed an AUC of 0.934. The ROC for predicting serious complications showed an AUC of 0.882. MiR-192-5p has the potential to be an adjunctive preoperative screening marker for cesarean section in patients with scarred uterus and has potential value in predicting the occurrence of complications after cesarean section, including PFD, vaginal microecological disorders, postoperative hemorrhage, abdominal incision infections, puerperal infections.

Keywords: caesarean section; complications; miR-192-5p; predictive; scarred uterus.