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Comment
. 2024 Nov;102(10):868-870.
doi: 10.1111/imcb.12822. Epub 2024 Sep 11.

The expanding universe of type I regulatory T cell biology: a new role in cancer immunotherapy

Jason F Nideffer  1 , Prasanna Jagannathan  1
Affiliations
Comment

The expanding universe of type I regulatory T cell biology: a new role in cancer immunotherapy

Jason F Nideffer et al. Immunol Cell Biol. 2024 Nov.

Abstract

In this article, we discuss new findings which suggest that type I regulatory T (Tr1) cells can interfere with cancer vaccine efficacy in mice by exerting strong regulatory control over antitumor immune responses.

Keywords: Antitumor immune responses; Tr1 cells; cancer immunotherapy; vaccines.

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Comment on

  • Neoantigen-specific cytotoxic Tr1 CD4 T cells suppress cancer immunotherapy.
    Sultan H, Takeuchi Y, Ward JP, Sharma N, Liu TT, Sukhov V, Firulyova M, Song Y, Ameh S, Brioschi S, Khantakova D, Arthur CD, White JM, Kohlmiller H, Salazar AM, Burns R, Costa HA, Moynihan KD, Yeung YA, Djuretic I, Schumacher TN, Sheehan KCF, Colonna M, Allison JP, Murphy KM, Artyomov MN, Schreiber RD. Sultan H, et al. Nature. 2024 Aug;632(8023):182-191. doi: 10.1038/s41586-024-07752-y. Epub 2024 Jul 24. Nature. 2024. PMID: 39048822 Free PMC article.

References

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