Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2024 Sep 11;14(1):21243.
doi: 10.1038/s41598-024-72248-8.

A prospective 10-year follow-up study after sublobar resection for ground-glass opacity-dominant lung cancer

Hirohisa Kato  1   2 , Satoshi Shiono  3   4 , Hiroyuki Suzuki  3   5 , Hidetaka Uramoto  3   6   7 , Jiro Abe  3   8 , Sumiko Maeda  3   9 , Tohru Hasumi  3   10 , Hiroyuki Deguchi  3   11 , Makoto Endo  3   12 , Nobuyuki Sato  3   13 , Masaya Aoki  3   14 , Jotaro Shibuya  3   15 , Motoyasu Sagawa  3   16 , Hirotsugu Notsuda  3   17 , Yoshinori Okada  3   17
Affiliations
Multicenter Study

A prospective 10-year follow-up study after sublobar resection for ground-glass opacity-dominant lung cancer

Hirohisa Kato et al. Sci Rep. .

Abstract

This single-arm multi-institutional prospective study aimed to evaluate the 10-year outcomes of sublobar resection for small-sized ground-glass opacity-dominant lung cancer. Among 73 patients prospectively enrolled from 13 institutions between November 2006 and April 2012, 53 ground-glass opacity-dominant lung cancer patients underwent sublobar resection with wedge resection as the first choice. The inclusion criteria were maximum tumor size of 8-20 mm; ≥ 80% ground-glass opacity ratio on high-resolution computed tomography; lower 18F-fluorodeoxyglucose accumulation than the mediastinum; intraoperative pathological diagnosis of adenocarcinoma in situ; and no cancer cells on intraoperative cut margins. The primary endpoint was a 10-year disease-specific survival. The 53 eligible patients had a mean tumor size of 14 ± 3.4 mm and a mean ground-glass opacity ratio of 95.9 ± 7.2%. Wedge resection and segmentectomy were performed in 39 and 14 patients, respectively. The final pathological diagnoses were adenocarcinoma in situ in 47 patients (88.7%) and adenocarcinoma with mixed subtype in 6 patients (11.3%). The 10-year disease-specific survival and overall survival were 100% and 96.2%, respectively, during a median follow-up period of 120 months (range, 37-162 months). Ground-glass opacity-dominant small lung cancer is cured by sublobar resection when patients are strictly selected by the inclusion criteria of this study.

Keywords: Computed tomography; Ground-glass opacity; Lung cancer; Positron emission tomography; Sublobar resection.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Representative case. Ground-glass opacity-dominant nodule.
Fig. 2
Fig. 2
Flowchart to determine the study eligibility of the patients with small-sized lung cancer who underwent sublobar resection.
Fig. 3
Fig. 3
Outcomes of the (a) 10-year disease-specific survival and (b) 10-year overall survival.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Kudo, Y. et al. Association between high-resolution computed tomography findings and the IASLC/ATS/ERS classification of small lung adenocarcinomas in Japanese patients. Lung Cancer90, 47–54 (2015). 10.1016/j.lungcan.2015.07.007 - DOI - PubMed
    1. Noguchi, M. et al. Small adenocarcinoma of the lung Histologic characteristics and prognosis. Cancer75, 2844–2852 (1995). 10.1002/1097-0142(19950615)75:12<2844::AID-CNCR2820751209>3.0.CO;2-# - DOI - PubMed
    1. Suzuki, K. et al. A single-arm study of sublobar resection for ground-glass opacity dominant peripheral lung cancer. J. Thorac. Cardiovasc. Surg.163, 289-301.e2 (2022). 10.1016/j.jtcvs.2020.09.146 - DOI - PubMed
    1. Sagawa, M. et al. A prospective 5-year follow-up study after limited resection for lung cancer with ground-glass opacity. Eur. J. Cardiothorac. Surg.53, 849–856 (2018). 10.1093/ejcts/ezx418 - DOI - PubMed
    1. Yoshida, J. et al. Possible delayed cut-end recurrence after limited resection for ground-glass opacity adenocarcinoma, intraoperatively diagnosed as Noguchi type B, in three patients. J. Thorac. Oncol.5, 546–550 (2010). 10.1097/JTO.0b013e3181d0a480 - DOI - PubMed

Publication types