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Review
. 2024 Aug 22;10(17):e36681.
doi: 10.1016/j.heliyon.2024.e36681. eCollection 2024 Sep 15.

Current insights and future directions of LncRNA Morrbid in disease pathogenesis

Haiqiong Yang  1   2 , Jiali Gao  3   4 , Zaiyong Zheng  1   2 , Yang Yu  1   2 , Chunxiang Zhang  1   2
Affiliations
Review

Current insights and future directions of LncRNA Morrbid in disease pathogenesis

Haiqiong Yang et al. Heliyon. .

Abstract

Non-coding RNAs have emerged as important regulators of gene expression and contributors to many diseases. LncRNA Morrbid, a long non-coding RNA, has been widely studied in recent years. Current literature reports that lncRNA Morrbid is involved in various diseases such as tumors, cardiovascular diseases, inflammatory diseases and metabolic disorder. However, controversial conclusions exist in current studies. As a potential therapeutic target, it is necessary to comprehensively review the current evidence. In this work, we carefully review the literature on Morrbid and discuss each of the hot topics related to lncRNA Morrbid.

Keywords: Cardiovascular disease; LncRNA Morrbid; Long non-coding RNA; MIR4435-2HG; Tumor.

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Conflict of interest statement

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Chunxiang Zhang reports financial support was provided by 10.13039/501100001809National Natural Science Foundation of China, China. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Morrbid contributes to the pathological process of multiple systemic tumors, hemooncology, inflammatory diseases, cardiovascular diseases and bone metabolism diseases.
Fig. 2
Fig. 2
Morrbid promotes the proliferation, migration and mesenchymal transition of tumor cells through the above signaling pathways (YAP1/TAZ, PI3K/Akt, Wnt/β-catenin, MAPK/ERK, JAKs/STATs, p53 pathway and TGF-β/SMAD2 pathway.
Fig. 3
Fig. 3
Morrbid may regulate metabolism by activating a key transcription factor FOXM1 in tumors.
See this image and copyright information in PMC

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