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. 2024 Aug 19;54(4):131-133.

Valproate-Autism Labyrinth

Affiliations
  • PMID: 39263199
  • PMCID: PMC11385261 (available on )

Valproate-Autism Labyrinth

Ahmed Naguy et al. Psychopharmacol Bull. .

Abstract

Valproate and Autism complexity is manifold. From an established environmental risk factor for autism, to a translational animal model, valproate's composite mode of action might unfold to address core autistic domains transcending mere aggressive behavioural control.

Keywords: autism; folic acid; irritability; risk; translational model; valproate.

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References

    1. Christensen J, Gronborg TK, Sorensen MJ et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA . 2013;309(16):1696–1703. - PMC - PubMed
    1. Wiggs KK, Rickert ME, Sujan AC et al. Antiseizure medication use during pregnancy and risk of ASD and ADHD in children. Neurology . 2020;95(24):e3232–e3240. - PMC - PubMed
    1. Ornoy A, Echefu B, Becker M. Valproic acid in pregnancy revisited: Neurobehavioral, biochemical and molecular changes affecting the embryo and fetus in humans and in animals: A narrative review. Int J Mol Sci . 2023;25(1):390. - PMC - PubMed
    1. Taleb A, Lin W, Xu X et al. Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment. Biomed Pharamcother . 2021;137:111322. - PubMed
    1. Adam A, Kemecsei R, Company V et al. Gestational exposure to sodium valproate disrupts fasciculation of the mesotelencephalic dopaminergic tract, with a selective reduction of dopaminergic output from the ventral tegmental area. Front Neuroanat . 2020;14:29. - PMC - PubMed

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