Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug 19;54(4):131-133.
doi: 10.64719/pb.4508.

Valproate-Autism Labyrinth

Ahmed Naguy  1 , Maryam Alqabandi  2
Affiliations

Valproate-Autism Labyrinth

Ahmed Naguy et al. Psychopharmacol Bull. .

Abstract

Valproate and Autism complexity is manifold. From an established environmental risk factor for autism, to a translational animal model, valproate's composite mode of action might unfold to address core autistic domains transcending mere aggressive behavioural control.

Keywords: autism; folic acid; irritability; risk; translational model; valproate.

PubMed Disclaimer

References

    1. Christensen J, Gronborg TK, Sorensen MJ et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA . 2013;309(16):1696–1703. - PMC - PubMed
    1. Wiggs KK, Rickert ME, Sujan AC et al. Antiseizure medication use during pregnancy and risk of ASD and ADHD in children. Neurology . 2020;95(24):e3232–e3240. - PMC - PubMed
    1. Ornoy A, Echefu B, Becker M. Valproic acid in pregnancy revisited: Neurobehavioral, biochemical and molecular changes affecting the embryo and fetus in humans and in animals: A narrative review. Int J Mol Sci . 2023;25(1):390. - PMC - PubMed
    1. Taleb A, Lin W, Xu X et al. Emerging mechanisms of valproic acid-induced neurotoxic events in autism and its implications for pharmacological treatment. Biomed Pharamcother . 2021;137:111322. - PubMed
    1. Adam A, Kemecsei R, Company V et al. Gestational exposure to sodium valproate disrupts fasciculation of the mesotelencephalic dopaminergic tract, with a selective reduction of dopaminergic output from the ventral tegmental area. Front Neuroanat . 2020;14:29. - PMC - PubMed

LinkOut - more resources