Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2024 Aug 22:37:e02066.
doi: 10.1016/j.idcr.2024.e02066. eCollection 2024.

Necrotizing pneumonia secondary to Influenza A (H1N1) coinfection with Staphylococcus aureus: A case report

Huibin Chen  1 , Hui Duan  1 , Jinling Zhao  1 , Kang Sun  1 , Keji Shan  1
Affiliations
Case Reports

Necrotizing pneumonia secondary to Influenza A (H1N1) coinfection with Staphylococcus aureus: A case report

Huibin Chen et al. IDCases. .

Abstract

Objective: This study aims to enhance understanding of necrotizing pneumonia and toxic shock syndrome by analyzing an adult case of community-acquired necrotizing pneumonia caused by co-infection of Influenza A (H1N1) and Staphylococcus aureus with LukS-PV and LukF-PV virulence factor genes.

Method: The clinical data of one patient admitted to the intensive care unit (ICU) with co-infection of Influenza A (H1N1) and Staphylococcus aureus was retrospectively analyzed.

Results: The patient exhibited typical clinical manifestations of viral and Staphylococcus aureus co-infection, including necrotizing pneumonia and toxic shock syndrome. The presence of LukS-PV and LukF-PV virulence factor genes of Staphylococcus aureus was detected in the patient's bronchoalveolar lavage fluid. Unfortunately，although antiviral agents (oseltamivir) and antibiotics (linezolid, imipenem-cilastatin) were timely administrated, as well as corticosteroids for anti-inflammatory purposes, the patient's condition was progressively deteriorated and eventually led to death.

Conclusion: Clinical practitioners should be vigilant about the co-infection of Influenza virus and Staphylococcus aureus, particularly when the latter carries virulence factors. The presence of virulence factor genes of Staphylococcus aureus can lead to necrotizing pneumonia with a poor prognosis. This is a particular concern because both infections can be life threatening in young adults.

Keywords: Co-infection; Influenza A virus (H1N1); LukF and LukS genes; Necrotizing pneumonia; Panton–Valentine leukocidin (PVL)-producing Staphylococcus aureus; Pneumonia; Toxic shock syndrome.

PubMed Disclaimer

Conflict of interest statement

I, Huibin Chen declare that there are no conflicts of interest in relation to the manuscript titled“Necrotizing Pneumonia Induced by Influenza A (H1N1) Concurrent with Staphylococcus aureus Infection: a Case Report”submitted to IDCases. IDCasesI confirm that the results and interpretations reported in the manuscript are original and have to been plagiarized. I certify that I have read and understand the IDCases conflict of interest policy, and I understand that failure to disclose a conflict of interest may result in the manuscript being rejected or retracted. I also certify that I have disclosed any financial or non-financial relationships that may be interpreted as constituting a conflict of interest in relation to this manuscript. I understand that this information will be subject to peer review, and I am willing to provide further information or clarification if required. I confirm that I have no known conflicts of interest that would influence the results or interpretation of the data presented in this manuscript, and I understand that failure to disclose a conflict of interest is unethical and may result in sanctions being imposed on me. Huibin Chen.

Figures

Fig. 1
Fig. 1
Chest CT shows patchy and nodular opacities with consolidation in the right lung and left lower lobe. Some lesions exhibit cavitations.
Fig. 2
Fig. 2
Changes in the absolute values of white blood cells, neutrophils, lymphocytes, red blood cells, hemoglobin, and platelets of the patient.
Fig. 3
Fig. 3
Annotation results from the CARD (Comprehensive Antibiotic Resistance Database) and VFDB (Virulence Factor Database) databases.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. Darboe S., et al. Prevalence of Panton-valentine leukocidin (PVL) and antimicrobial resistance in community-acquired clinical Staphylococcus aureus in an urban gambian hospital: A 11-year period retrospective pilot study. Front Cell Infect Microbiol. 2019;9:170. - PMC - PubMed
    1. Krutikov M., Rahman A., Tiberi S. Necrotizing pneumonia (aetiology, clinical features and management) Curr Opin Pulm Med. 2019;25(3):225–232. - PubMed
    1. Bubeck Wardenburg J., et al. Poring over pores: alpha-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia. Nat Med. 2007;13(12):1405–1406. - PubMed
    1. Yangyang Li, Peng peng. Progress of research on community-acquired methicillin-resistant Staphylococcus aureus. Chin J Nosocomiology. 2011;21(05):1056–1058.
    1. Niemann S., et al. Combined action of influenza virus and Staphylococcus aureus panton-valentine leukocidin provokes severe lung epithelium damage. J Infect Dis. 2012;206(7):1138–1148. - PMC - PubMed

Publication types

LinkOut - more resources