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. 2024 Aug 17;18(15-16):649-658.
doi: 10.1080/17520363.2024.2377532. Epub 2024 Sep 12.

Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns

Joycilene da Silva Barbosa  1 , Gdayllon Cavalcante Meneses  2 , Luan Rebouças Castelo  1 , Geraldo Bezerra da Silva Júnior  3 , Alice Maria Costa Martins  4 , Elizabeth De Francesco Daher  2 , Tiago Lima Sampaio  4 , Amanda de Oliveira Gomes  1 , Suzzy Maria Carvalho Dantas  1 , Arthur da Silva Rebouças  5 , Paula Roberta de Lima  2 , Nicole Coelho Lopes  4 , Mateus Edson da Silva  4 , Mac Dionys Rodrigues da Costa  4 , Ana Amelia Reis Jereissati  6 , Victoria Queiroz Ramos  7 , Rosângela Pinheiro Gonçalves Machado  8 , Romélia Pinheiro Gonçalves Lemes  4
Affiliations

Urinary cystatin-C and urinary NGAL associated with sepsis predicts longer hospital stay in premature newborns

Joycilene da Silva Barbosa et al. Biomark Med. .

Abstract

Aim: To evaluate the urinary biomarkers related to sepsis in preterm newborns (NBs) and to investigate the predictive capacity of these biomarkers for a longer hospital stay.Methods: Serum and urine were collected from 27 healthy NBs, 24 NBs with neonatal infection without sepsis and 11 NBs with sepsis for the measurement of sindecan-1, lipocalin associated with urinary neutrophil gelatinase (uNGAL), urinary cystatin-C (uCysC) and urinary kidney injury molecule-1.Results: Levels of uNGAL and urinary cystatin-C were elevated in NBs with sepsis and neonatal infection, and uNGAL was significant predictor of hospital stay longer than 30 days (odds ratio: 1.052; 95% CI: 1.012-1.093; p = 0.01).Conclusion: uNGAL was associated with sepsis in preterm NBs and was useful to predict extended hospital stay.

Keywords: acute kidney injury; biomarkers; newborns; premature; sepsis.

Plain language summary

[Box: see text].

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Conflict of interest statement

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

Figures

Figure 1.
Figure 1.
Study population flowchart.
Figure 2.
Figure 2.
ng/mg-cr: nanogram per milligram per creatinine; Levels of uCysC and Lipocalin associated with uNGAL in newborns according to a longer hospital stay determined by more than 30 days. uCysC: Urinary Cystatin C; uNGAL: Urinary neutrophil gelatinase.
Figure 3.
Figure 3.
Performance of uCysC and Lipocalin associated with uNGAL in predict longer hospital stay in newborns. AUC: Area under the curve; ng/mg-cr: Nanogram per milligram per creatinine; uCysC: Urinary Cystatin C; uNGAL: Urinary neutrophil gelatinase.
See this image and copyright information in PMC

References

    1. Camacho-Gonlazes A, Spearman PW, Stoll BJ. Neonatal infectious diseases: evaluation of neonatal sepsis. Pediatr Clin North America. 2013;60(2):367–389. doi: 10.1016/j.pcl.2012.12.003 - DOI - PMC - PubMed
    1. Russel ARB, Neonatal sepsis . Neonatal sepsis. Paediatr Int Child Health. 2015;25(6):271–275. doi: 10.1016/j.paed.2015.02.005 - DOI
    1. Lee CW, Kou HW, Chou HS. A combination of SOFA score and biomarkers gives a better prediction of septic AKI and in-hospital mortality in critically ill surgical patients: a pilot study. World J Emerg Surg. 2018;13:1–11. doi: 10.1186/s13017-018-0202-5 - DOI - PMC - PubMed

    2. • Shows the levels of urinary neutrophil gelatinase (uNGAL) were associated with neonatal infection or sepsis, corroborating with a previous study in which patients with septic acute kidney injury (AKI) showed significantly higher levels of these biomarkers when compared to those without this condition.

    1. Liborio AB, Branco KM, Bezerra CTM. Acute kidney injury in neonates: from urine output to new biomarkers. Biomed Res Int. 2014;2014:1–8. doi: 10.1155/2014/601568 - DOI - PMC - PubMed
    1. Agência Nacional de Vigilância Sanitária . Diagnostic criteria for healthcare-associated infection: neonatology].2017;19–21. Portuguese. https://www.gov.br/anvisa/pt-br/centraisdeconteudo/publicacoes/servicosd...