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. 2024 Aug;177(4):449-453.
doi: 10.1007/s10517-024-06206-9. Epub 2024 Sep 12.

Endocytosis of Synaptic Vesicle in Motor Nerve Endings of FUS Transgenic Mice with a Model of Amyotrophic Lateral Sclerosis

P N Grigoryev  1 , G A Gaptrakhmanova  1 , A A Plotnikova  1 , A L Zefirov  1 , M A Mukhamedyarov  2
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Endocytosis of Synaptic Vesicle in Motor Nerve Endings of FUS Transgenic Mice with a Model of Amyotrophic Lateral Sclerosis

P N Grigoryev et al. Bull Exp Biol Med. 2024 Aug.

Abstract

In experiments on the motor nerve endings of the diaphragm of transgenic FUS mice with a model of amyotrophic lateral sclerosis at the pre-symptomatic stage of the disease, the processes of transmitter release and endocytosis of synaptic vesicles were studied. In FUS mice, the intensity of transmitter release during high-frequency stimulation of the motor nerve (50 imp/sec) was lowered. At the same duration of stimulation, the loading of fluorescent dye FM1-43 was lower in FUS mice. However, at the time of stimulation, during which an equal number of quanta are released in wild-type and FUS mice, no differences in the intensity of dye loading were found. Thus, endocytosis is not the key factor in the mechanism of synaptic dysfunction in FUS mice at the pre-symptomatic stage.

Keywords: amyotrophic lateral sclerosis; neuromuscular junction; synaptic vesicle endocytosis; transgenic FUS1-359 mice; transmitter release.

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