Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug;177(4):488-492.
doi: 10.1007/s10517-024-06212-x. Epub 2024 Sep 12.

The Influence of Metabolites of Microorganisms of the Genus Bacillus from Permafrost Rocks on T Lymphocyte Differentiation

S A Petrov  1 , Yu G Sukovey  2 , L F Kalenova  2 , E G Kostolomova  3 , A M Subbotin  2 , M V Narushko  2 , A S Bazhin  2
Affiliations

The Influence of Metabolites of Microorganisms of the Genus Bacillus from Permafrost Rocks on T Lymphocyte Differentiation

S A Petrov et al. Bull Exp Biol Med. 2024 Aug.

Abstract

We studied the influence of metabolites of permafrost microorganisms obtained at different temperature incubation conditions on activity of differentiation of regulatory (Treg) and effector T lymphocytes. It was found that the effect of metabolites is largely regulated by their type that depends on the temperature of production ("cold" at 5°C, "medium temperature" at 22°C, and "warm" at 37°C). The studied metabolites influenced the differentiation of Tregs (CD4+CD25hiCD127-) and the expression of markers of early (CD69), middle (CD25), and late (HLA DR) activation of CD4+ and CD8+ T lymphocytes. In the case of "cold" metabolites, the increase in Treg levels was associated with a decrease in the intensity of CD4+ T lymphocyte differentiation, and under the influence of "warm" metabolites - with a decrease in the activity of CD8+ T lymphocyte differentiation. Under the influence of "medium-temperature" metabolites, Tregs had approximately the same effect on the intensity of CD4+ and CD8+ T lymphocyte differentiation.

Keywords: CD4+CD25hiCD127— Treg; CD69, CD25, HLA DR T lymphocytes; bacterial metabolites; factors regulating lymphocyte differentiation; microorganisms of the genus Bacillus from permafrost rocks.

PubMed Disclaimer

References

    1. Freidlin IS. Regulatory t-cells: origin and function. Med. Immunol. 2005;7(4):347-354. Russian. https://doi.org/10.15789/1563-0625-2005-4-347-354
    1. Zurochka AV, Khaidukov SV. Analysis of T-helper subpopulations (Th1, Th2, Treg, Th17, activated T-helpers) by means of flow cytometry. Med. Immunol. 2011;13(1):7-16. Russian. https://doi.org/10.15789/1563-0625-2011-1-7-16
    1. Athanassakis I, Vassiliadis S. T-regulatory cells: are we re-discovering T suppressors? Immunol. Lett. 2002;84(3):179-183. https://doi.org/10.1016/s0165-2478(02)00182-7 - DOI - PubMed
    1. Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 2005;6(4):331-337. https://doi.org/10.1038/ni1179 - DOI - PubMed
    1. Cibrián D, Sánchez-Madrid F. CD69: from activation marker to metabolic gatekeeper. Eur. J. Immunol. 2017;47(6):946-953. https://doi.org/10.1002/eji.201646837 - DOI - PubMed - PMC

MeSH terms

LinkOut - more resources