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. 2025 Apr;39(4):e347-e349.
doi: 10.1111/jdv.20336. Epub 2024 Sep 12.

Concurrent intrathecal nivolumab and targeted therapy in a patient with melanoma-associated leptomeningeal disease

Emma Chevallier  1 , Violaine Flory  2 , Madleen Chassang  2 , Emma Huard  1 , Fanny Burel-Vandenbos  3 , Thierry Passeron  1 , Henri Montaudié  1
Affiliations

Concurrent intrathecal nivolumab and targeted therapy in a patient with melanoma-associated leptomeningeal disease

Emma Chevallier et al. J Eur Acad Dermatol Venereol. 2025 Apr.
No abstract available

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References

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    1. Tawbi HA, Forsyth PA, Hodi FS, Algazi AL, Hamid O, Lao CD, et al. Long‐term outcomes of patients with active melanoma brain metastases treated with combination nivolumab plus ipilimumab (CheckMate 204): final results of an open‐label, multicentre, phase 2 study. Lancet Oncol. 2021;22(12):1692–1704.
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    1. Glitza Oliva IC, Ferguson SD, Bassett R, Foster AP, John I, Hennegan TD, et al. Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results. Nat Med. 2023;29:898–905.
    1. Glitza IC, Rohlfs M, Guha‐Thakurta N, Basset RL, Bernatchez C, Diab A, et al. Retrospective review of metastatic melanoma patients with leptomeningeal disease treated with intrathecal interleukin‐2. ESMO Open. 2018;3(1):e000283.

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