Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 12;19(9):e0308497.
doi: 10.1371/journal.pone.0308497. eCollection 2024.

Developmental dyslexia in children with perinatal exposure to hypoxia: A systematic review

Bartosz M Radtke  1 , Małgorzata Lipowska  2 , Łucja Bieleninik  2   3   4 , Ariadna Łada-Maśko  2 , Katarzyna Krempla-Patron  5 , Rafał Nowicki  1 , Gabriela Gradys  2 , Anna Brykała  2 , Judyta Pacuła  2 , Marek Arasimowicz  2 , Urszula Sajewicz-Radtke  1
Affiliations

Developmental dyslexia in children with perinatal exposure to hypoxia: A systematic review

Bartosz M Radtke et al. PLoS One. .

Abstract

Background: Research on a health-related event at the stage of labour and the occurrence of adverse outcomes at the school age has provided inconclusive results. Thus far, no systematic reviews have been conducted. Thus, the objective of this study is to investigate the association between hypoxia during pregnancy or delivery and the subsequent occurrence of a developmental dyslexia in school-age children.

Methods: We used a standard search strategy of electronic databases (PubMed, PsycINFO, Web of Science, EMBASE, and Cochrane Library) and handsearching. We included observational studies (cohort studies, case-control studies) that consider as an exposure the presence of hypoxia during pregnancy or delivery, and as an outcome, developmental dyslexia in school-age children. Two reviewers independently conducted the search and determined eligibility, which was not restricted by language or year of publication.

Results: The search took place until 1 April 2023. Of the 1,336 abstracts screened, 6 were assessed for eligibility. Of the six eligible studies, no studies met the pre-specified eligibly criteria.

Conclusions: We were unable to assess the association between hypoxia and developmental dyslexia, as no eligible studies were found. Thus, the association between hypoxia during pregnancy or delivery and dyslexia in school-age children remains unknown.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Study flow diagram.
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. WHO. International Classification of Diseases for Mortality and Morbidity Statistics (11th Revision) 2019 [https://icd.who.int/browse11/l-m/en.]
    1. WHO. The ICD-10 Classification of Mental and Behavioural Disorders: Diagnostic Criteria for Research. Geneva: World Health Organization; 1993.
    1. Norbury CF, Sparks A. Difference or disorder? Cultural issues in understanding neurodevelopmental disorders. Developmental Psychology. 2013;49 1:45–58. doi: 10.1037/a0027446 - DOI - PubMed
    1. Ramus F, White S, Frith U. Weighing the evidence between competing theories of dyslexia. Developmental Science. 2006;9(3):265–9. - PubMed
    1. Nicolson RI, Fawcett AJ, Dean P. Developmental dyslexia: The cerebellar deficit hypothesis. Trends in Neurosciences. 2001;24(9):508–11. doi: 10.1016/s0166-2236(00)01896-8 - DOI - PubMed

Publication types

LinkOut - more resources