Cardiac mechano-electric crosstalk: multi-scale observations, computational integration, and clinical implications

Ramona Emig¹, Eilidh A MacDonald², T Alexander Quinn^{3

4}

Affiliations

¹ Department of Immunology, Tufts University School of Medicine, Boston, USA.
² School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
³ Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
⁴ School of Biomedical Engineering, Dalhousie University, Halifax, Canada.

Free article

Editorial

Ramona Emig et al. J Physiol. 2024 Sep.

Free article

. 2024 Sep;602(18):4335-4340.

doi: 10.1113/JP286706. Epub 2024 Sep 12.

Ramona Emig¹, Eilidh A MacDonald², T Alexander Quinn^{3

4}

¹ Department of Immunology, Tufts University School of Medicine, Boston, USA.
² School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.
³ Department of Physiology and Biophysics, Dalhousie University, Halifax, Canada.
⁴ School of Biomedical Engineering, Dalhousie University, Halifax, Canada.

No abstract available

Keywords: calcium; computational modelling; heart; mechano‐electric coupling; mechano‐sensitivity; stretch; stretch‐activated channels.

References

1. Alim, C. C., Ko, C. Y., Mira Hernandez, J., Shen, E. Y., Baidar, S., Chen‐Izu, Y., Bers, D. M., & Bossuyt, J. (2022). Nitrosylation of cardiac CaMKII at Cys290 mediates mechanical afterload‐induced increases in Ca2+ transient and Ca2+ sparks. The Journal of Physiology, 600(22), 4865–4879.
1. Amini, N. (2024). The emergence of deep learning as the current state of art for classification and risk assessment of ventricular arrhythmias. The Journal of Physiology, 602(18), 4645–4647.
1. Aschieri, D., Guerra, F., Pelizzoni, V., Paolini, E., Stronati, G., Moderato, L., Losi, G., Compagnucci, P., Coccia, M., Casella, M., Dello Russo, A., Bardy, G. H., & Capucci, A. (2021). Ventricular fibrillation recurrences in successfully shocked out‐of‐hospital cardiac arrests. Medicina (Kaunas, Lithuania), 57(4), 358.
1. Baillie, J. S., Gendernalik, A., Garrity, D. M., Bark, D., & Quinn, T. A. (2023). The in vivo study of cardiac mechano‐electric and mechano‐mechanical coupling during heart development in zebrafish. Frontiers in Physiology, 14, 1086050.
1. Buonocunto, M., Lyon, A., Delhaas, T., Heijman, J., & Lumens, J. (2023). Electrophysiological effects of stretch‐activated ion channels: A systematic computational characterization. The Journal of Physiology, 602(18), 4585–4604.