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Multicenter Study
. 2024 Nov:190:272-282.
doi: 10.1016/j.ygyno.2024.09.006. Epub 2024 Sep 11.

Cervical squamous cell carcinoma outcomes across continents: A retrospective study

Deepti Jain  1 , Fadi Zaeim  1 , Marya Wahidi  2 , William J Smith  1 , Waed Alkaram  1 , Asem Abu-Jamea  3 , Sanaa Awada  1 , Lien Hoang  4 , Anna Pesci  5 , Ricardo R Lastra  6 , Takako Kiyokawa  7 , Esther Oliva  8 , Kyle Devins  8 , Hyejeong Jang  9 , Seongho Kim  9 , Terrence Wong  10 , Radhika Gogoi  10 , Robert Morris  10 , Claudia Mateoiu  11 , Sudeshna Bandyopadhyay  12 , Simona Stolnicu  13 , Robert Soslow  14 , Rouba Ali-Fehmi  15
Affiliations
Multicenter Study

Cervical squamous cell carcinoma outcomes across continents: A retrospective study

Deepti Jain et al. Gynecol Oncol. 2024 Nov.

Abstract

Objective: To assess the influence of geographies and race on the survival outcomes in patients diagnosed with cervical squamous cell carcinoma (CSCC) across three continents.

Methods: This multicontinental retrospective study was conducted in 8 hospitals across Asia, Europe, and North America (NA). Clinicopathologic data of 595 patients with presumed early stages of CSCC, treated surgically, with curative intent was collected. Descriptive analysis and Cox regression models were produced.

Results: A total of 595 patients, consisting of 445 (74.8 %) white, 75 (12.6 %) Blacks, and 75 (12.6 %) Asian patients were included. Geographical distribution comprised 69 % of patients from NA, 22 % from Europe, and 9 % from Asia. The median age at diagnosis was 46 years. The median overall survival (OS) and relapse-free survival (RFS) were 22.09 years and 21.19 years, respectively. Patient characteristics varied significantly across geographical regions, except for consensus tumor grade. Patients in Europe from middle-income countries with limited CC screening had a substantially higher risk of death than those in NA (HR, 1.79; 95 % CI, 1.13 to 2.79; p = 0.015). Patients from single center in Japan had higher risk of relapse than those from the four heterogeneous NA centers (sub-distribution hazard ratio, 2.19; 95 % CI, 1.22 to 3.95; p = 0.009), although OS did not differ significantly. Race remained statistically insignificant for survival outcomes across the three continents but seemed to influence survival outcomes in NA centers.

Conclusion: Our study highlights impact of geographies and races on CSCC survival outcomes, emphasizing the need of considering these factors when developing targeted interventions against CSCC.

Keywords: CSCC; Cervical cancer; Cervical squamous cell carcinoma; Geographies; Race; Survival outcomes.

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Conflict of interest statement

Declaration of competing interest The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers' bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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