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. 2024 Sep 11;4(9):100652.
doi: 10.1016/j.xgen.2024.100652.

Missing regulatory effects and viral triggers explored for childhood-onset asthma

Hai Fang  1
Affiliations

Missing regulatory effects and viral triggers explored for childhood-onset asthma

Hai Fang. Cell Genom. .

Abstract

Missing regulatory effects of asthma genetic risks might be hidden within specific cell states. In this issue of Cell Genomics, Djeddi et al.1 uncover how airway epithelial cells, when activated by rhinovirus, influence genetic susceptibility to childhood-onset asthma, and this preview emphasizes the need to address these missing regulatory effects across diverse cell states.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

Figures

Figure 1
Figure 1
Interplay between genetic factors and environmental factors in COA The yin-yang-like illustration in the middle panel vividly depicts the interplay between child-onset asthma (COA) genetics and environmental factors (cell types + viral triggers; e.g., rhinovirus infection of non-ciliated airway epithelial cells) in driving COA, as explored by Djeddi and colleagues. In this preview, Fang outlines future challenges and directions for further resolving "missing regulatory effects" across diverse cell states; for example, identifying more subsets and states of COA-related cell types infected by multiple types of respiratory viruses that interact with COA genetic risk factors.
See this image and copyright information in PMC

References

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