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Observational Study
. 2024 Nov;133(5):1073-1084.
doi: 10.1016/j.bja.2024.08.005. Epub 2024 Sep 11.

Association between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study

Nicholas J Douville  1 , Mark E Smolkin  2 , Bhiken I Naik  3 , Michael R Mathis  4 , Douglas A Colquhoun  4 , Sachin Kheterpal  4 , Stephen R Collins  3 , Linda W Martin  5 , Wanda M Popescu  6 , Nathan L Pace  7 , Randal S Blank  8 ; Multicentre Perioperative Clinical Research Committee
Collaborators, Affiliations
Observational Study

Association between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study

Nicholas J Douville et al. Br J Anaesth. 2024 Nov.

Abstract

Background: Limited data exist to guide oxygen administration during one-lung ventilation for thoracic surgery. We hypothesised that high intraoperative inspired oxygen fraction during lung resection surgery requiring one-lung ventilation is independently associated with postoperative pulmonary complications (PPCs).

Methods: We performed this retrospective multicentre study using two integrated perioperative databases (Multicenter Perioperative Outcomes Group and Society of Thoracic Surgeons General Thoracic Surgery Database) to study adult thoracic surgical procedures using one-lung ventilation. The primary outcome was a composite of PPCs (atelectasis, acute respiratory distress syndrome, pneumonia, respiratory failure, reintubation, and prolonged ventilation >48 h). The exposure of interest was high inspired oxygen fraction (FiO2), defined by area under the curve of a FiO2 threshold > 80%. Univariate analysis and logistic regression modelling assessed the association between intraoperative FiO2 and PPCs.

Results: Across four US medical centres, 141/2733 (5.2%) procedures conducted in 2716 patients (55% female; mean age 66 yr) resulted in PPCs. FiO2 was univariately associated with PPCs (adjusted OR [aOR]: 1.17, 95% confidence interval [CI]: 1.04-1.33, P=0.012). Logistic regression modelling showed that duration of one-lung ventilation (aOR: 1.20, 95% CI: 1.03-1.41, P=0.022), but not the time-weighted average FiO2 (aOR: 1.01, 95% CI: 1.00-1.02, P=0.165), was associated with PPCs.

Conclusions: Our results do not support limiting the inspired oxygen fraction for the purpose of reducing postoperative pulmonary complications in thoracic surgery involving one-lung ventilation.

Keywords: hyperoxia; inspired oxygen fraction; lung resection; one-lung ventilation; postoperative pulmonary complications; protective ventilation; single-lung ventilation; thoracic surgery.

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Conflict of interest statement

The authors declare that they have no conflicts of interest beyond those described in the funding statement.

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