Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Chase Hall reports a relationship with Polarean, Inc that includes: consulting or advisory. Chase Hall reports a relationship with GSK that includes: consulting or advisory and speaking and lecture fees. Chase Hall reports a relationship with Boehringer Ingelheim Pharmaceuticals Inc that includes: consulting or advisory and speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.