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. 1985 Apr;36(4):263-7.
doi: 10.1016/0020-708x(85)90082-1.

Syntheses of carbon-11 labelled ornithine and lysine. Preliminary accumulation studies in rats with Walker 256 carcinosarcoma

J M Bolster, W Vaalburg, T H van Dijk, J B Zijlstra, A M Paans, H Wynberg, M G Woldring

Syntheses of carbon-11 labelled ornithine and lysine. Preliminary accumulation studies in rats with Walker 256 carcinosarcoma

J M Bolster et al. Int J Appl Radiat Isot. 1985 Apr.

Abstract

DL-[1-11C]ornithine and lysine have been synthesized by carboxylation of the corresponding alpha-lithioisocyanide with a radiochemical yield of up to 14% without correction for decay. The total preparation time is 50 min. Accumulation of both DL-[1-11C]ornithine and lysine in Walker 256 carcinosarcoma is observed, with a tumor/non-tumor ratio of 4.9 and 4.5 respectively, at 45 min after intravenous injection.

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