Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

Florence Rabian¹, Sylvie Chevret², Bérengère Gruson³, Sylvain Thépot⁴, Anouk Walter-Petrich², Thorsten Braun⁵, Norbert Vey⁶, José Miguel Torregrosa-Diaz⁷, Pierre Peterlin⁸, Andrea Toma⁹, Maud D'Aveni¹⁰, Jacques Delaunay¹¹, Laurence Legros¹², Nathalie Droin¹³, Fatiha Chermat¹⁴, Daniel Lusina¹⁵, Lionel Adès^{1

16}, Rosa Sapena¹⁴, Eric Solary¹³, Pierre Fenaux^{1

16}, Raphael Itzykson^{17

18}

Affiliations

¹ Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.
² SBIM, APHP, Hôpital Saint-Louis, INSERM, UMR-1153, ECSTRRA Team, Paris, France.
³ Hematology Department CHU Amiens, Amiens, France.
⁴ Hematology Department CHU Angers, Université Angers, Angers, France.
⁵ Hematology Department, Hôpital Avicenne, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
⁶ Hematology Department, Institut Paoli-Calmettes, Marseille, France.
⁷ Service d'Hématologie Oncologique et Thérapie Cellulaire, CIC INSERM 1402, University Hospital of Poitiers, Poitiers, France.
⁸ Hematology Department CHU Nantes, Université Nantes, Nantes, France.
⁹ Geriatric Hematology Unit, Hopitaux Universitaires Henri Mondor, Assistance Publique-Hopitaux-de-Paris, Draveil, France.
¹⁰ Hematology Department, University Hospital of Nancy, Nancy, France.
¹¹ Hematology Unit, Hôpital Privé Le Confluent, Nantes, France.
¹² Department of Hematology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre, France.
¹³ Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.
¹⁴ Groupe Francophone des Myélodysplasies, F-75010, Paris, France.
¹⁵ Hematology Laboratory, Hôpital Avicenne, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
¹⁶ Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010, Paris, France.
¹⁷ Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France. raphael.itzykson@aphp.fr.
¹⁸ Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010, Paris, France. raphael.itzykson@aphp.fr.

PMID: 39266637
DOI: 10.1038/s41375-024-02402-8

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

Florence Rabian et al. Leukemia. 2024 Nov.

. 2024 Nov;38(11):2510-2513.

doi: 10.1038/s41375-024-02402-8. Epub 2024 Sep 12.

Authors

Affiliations

¹ Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France.
² SBIM, APHP, Hôpital Saint-Louis, INSERM, UMR-1153, ECSTRRA Team, Paris, France.
³ Hematology Department CHU Amiens, Amiens, France.
⁴ Hematology Department CHU Angers, Université Angers, Angers, France.
⁵ Hematology Department, Hôpital Avicenne, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
⁶ Hematology Department, Institut Paoli-Calmettes, Marseille, France.
⁷ Service d'Hématologie Oncologique et Thérapie Cellulaire, CIC INSERM 1402, University Hospital of Poitiers, Poitiers, France.
⁸ Hematology Department CHU Nantes, Université Nantes, Nantes, France.
⁹ Geriatric Hematology Unit, Hopitaux Universitaires Henri Mondor, Assistance Publique-Hopitaux-de-Paris, Draveil, France.
¹⁰ Hematology Department, University Hospital of Nancy, Nancy, France.
¹¹ Hematology Unit, Hôpital Privé Le Confluent, Nantes, France.
¹² Department of Hematology, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre, France.
¹³ Université Paris Saclay, INSERM U1287, Gustave Roussy Cancer Center, Villejuif, France.
¹⁴ Groupe Francophone des Myélodysplasies, F-75010, Paris, France.
¹⁵ Hematology Laboratory, Hôpital Avicenne, Université Sorbonne Paris Nord, Assistance Publique-Hôpitaux de Paris, Bobigny, France.
¹⁶ Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010, Paris, France.
¹⁷ Hematology Department, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, F-75010, Paris, France. raphael.itzykson@aphp.fr.
¹⁸ Université Paris Cité, Génomes, biologie cellulaire et thérapeutique U944, INSERM, CNRS, F-75010, Paris, France. raphael.itzykson@aphp.fr.

PMID: 39266637
DOI: 10.1038/s41375-024-02402-8

No abstract available

PubMed Disclaimer

References

1. Solary E, Itzykson R. How I treat chronic myelomonocytic leukemia. Blood. 2017;130:126–36. - DOI - PubMed
1. Itzykson R, Fenaux P, Bowen D, Cross NCP, Cortes J, De Witte T, et al. Diagnosis and Treatment of Chronic Myelomonocytic Leukemias in Adults: Recommendations From the European Hematology Association and the European LeukemiaNet. Hemasphere. 2018;2:e150. - DOI - PubMed - PMC
1. Oliva EN, Riva M, Niscola P, Santini V, Breccia M, Giai V, et al. Eltrombopag for Low-Risk Myelodysplastic Syndromes With Thrombocytopenia: Interim Results of a Phase II, Randomized, Placebo-Controlled Clinical Trial (EQOL-MDS). J Clin Oncol. 2023;41:4486–96. - DOI - PubMed - PMC
1. Modi Y, Shaaban H, Gauchan D, Maroules M. Successful treatment of severe thrombocytopenia with the use of thrombopoeitin receptor agonist eltrombopag in a patient with chronic myelomonocytic leukemia. J Oncol Pharm Pr. 2015;21:74–75. - DOI
1. Gao Y, Gong M, Zhang C, Kong X, Ma Y. Successful eltrombopag treatment of severe refractory thrombocytopenia in chronic myelomonocytic leukemia: Two cases reports: A CARE-compliant article. Medicine. 2017;96:e8337. - DOI - PubMed - PMC

Grants and funding

INCa-DGOS-INSERM-ITMO Cancer_18008/Institut National Du Cancer (French National Cancer Institute)

LinkOut - more resources

Full Text Sources
- Nature Publishing Group

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

Affiliations

Eltrombopag in chronic myelomonocytic leukemia with severe thrombocytopenia. A Groupe Francophone des Myélodysplasies (GFM) study

Authors

Affiliations

References

Grants and funding

LinkOut - more resources

Full Text Sources