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Editorial
. 2024 Oct;31(10):1239-1241.
doi: 10.1038/s41418-024-01372-9. Epub 2024 Sep 12.

Feeding cancer to death - a triad of aromatic acids reduces tumor growth

Audrey Xavier  1   2 , Ivan Dikic  3   4   5
Affiliations
Editorial

Feeding cancer to death - a triad of aromatic acids reduces tumor growth

Audrey Xavier et al. Cell Death Differ. 2024 Oct.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Aromatic amino acid supplementation induces tumor cell death.
A During physiological conditions Sestrin3 interacts with and inhibits GATOR2 and mTOR mediated proteasome shuttling. This allows the proteasome to transcolate to the cytosol, replenish nutrients by proteolysis and facilitate tumor growth, B Supplementation of the aromatic amino acids Tyr, Trp, and Phe (YWF) to tumor cells activates mTOR, a signal mediated via a novel sensor, Sestrin3. This activation results in sequestration of the proteasome in the nucleus, inhibition of cytosolic proteolysis, and subsequent tumor cell death.
See this image and copyright information in PMC

References

    1. Vander Heiden MG, DeBerardinis RJ. Understanding the Intersections between Metabolism and Cancer Biology. Cell. 2017;168:657–69. - PMC - PubMed
    1. Livneh I, Fabre B, Goldhirsh G, Lulu C, Zinger A, Shammai Y. Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3 - their sensing mediator - is tumor suppressive. Cell Death Differ. 2024. 10.1038/s41418-024-01370-x. - PMC - PubMed
    1. Saxton RA, Sabatini DM. mTOR Signaling in Growth, Metabolism, and Disease. Cell. 2017;168:960–76. - PMC - PubMed
    1. González A, Hall MN. Nutrient sensing and TOR signaling in yeast and mammals. EMBO J. 2017;36:397–408. - PMC - PubMed
    1. Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, et al. A tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1. Science. 2013;340:1100–6. - PMC - PubMed

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