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Randomized Controlled Trial
. 2024 Nov;26(11):5431-5443.
doi: 10.1111/dom.15922. Epub 2024 Sep 12.

Ultra-processed foods cause weight gain and increased energy intake associated with reduced chewing frequency: A randomized, open-label, crossover study

Shoko Hamano  1 , Mika Sawada  2 , Masakazu Aihara  1 , Yoshitaka Sakurai  1 , Rie Sekine  2 , Satoshi Usami  3 , Naoto Kubota  4 , Toshimasa Yamauchi  1
Affiliations
Randomized Controlled Trial

Ultra-processed foods cause weight gain and increased energy intake associated with reduced chewing frequency: A randomized, open-label, crossover study

Shoko Hamano et al. Diabetes Obes Metab. 2024 Nov.

Abstract

Aim: To elucidate the effects of ultra-processed foods (UPFs) on body weight and ad libitum energy intake compared with non-UPFs.

Materials and methods: In this randomized, open-label crossover study conducted at the University of Tokyo Hospital, overweight/obese Japanese male participants were randomly assigned (1:1) to start the study with consumption of either UPFs or non-UPFs for 1 week, followed by a 2-week washout period, before crossing over to the alternate food diet for 1 week. Individuals with diabetes, hypertension or any other medical conditions who visited a hospital regularly were excluded. The meals were designed to be matched for the total energy and macronutrient levels. The primary outcome was the difference in the body weight change between the UPF and non-UPF periods. The differences in the average daily energy intake and chewing frequency were assessed as one of the prespecified secondary outcomes.

Results: Nine eligible participants were randomly assigned to start the study with either UPFs or non-UPFs. All participants completed the study. During the UPF period, participants gained 1.1 kg more weight (95% confidence interval 0.2 to 2.0; P = .021) and consumed 813.5 kcal more per day (342.4 to 1284.7; P = .0041) compared with during the non-UPF period. Regarding the chewing frequency, the number of chews per calorie was significantly lower during the UPF period (P = .016).

Conclusions: Consumption of UPFs causes significant weight gain. Medical nutritional therapy focused on reducing the consumption of UPFs could be an effective strategy for preventing obesity.

Keywords: appetite control; clinical trial; obesity therapy; randomized trial.

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References

REFERENCES

    1. GBD 2016 Causes of Death Collaborators. Global, regional, and national age‐sex specific mortality for 264 causes of death, 1980‐2016: a systematic analysis for the global burden of disease study 2016. Lancet. 2017;390(10100):1151‐1210. doi:10.1016/S0140‐6736(17)32152‐9
    1. Monteiro CA, Moubarac JC, Cannon G, Ng SW, Popkin B. Ultra‐processed products are becoming dominant in the global food system. Obes Rev. 2013;14(Suppl 2):21‐28. doi:10.1111/obr.12107
    1. Monteiro CA, Cannon G, Levy R, et al. The star shines bright. World Nutr. 2016;7(1–3):28‐38.
    1. Monteiro CA, Cannon G, Moubarac J‐C, Levy RB, Louzada MLC, Jaime PC. The UN decade of nutrition, the NOVA food classification and the trouble with ultra‐processing. Public Health Nutr. 2018;21(1):5‐17. doi:10.1017/s1368980017000234
    1. Monteiro CA, Moubarac JC, Levy RB, Canella DS, Louzada M, Cannon G. Household availability of ultra‐processed foods and obesity in nineteen European countries. Public Health Nutr. 2018;21(1):18‐26. doi:10.1017/S1368980017001379

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