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. 2024 Aug 29:15:1446730.
doi: 10.3389/fimmu.2024.1446730. eCollection 2024.

Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers

Eva Poveda  1 , Wendy Fitzgerald  2 , Jacobo Alonso-Domínguez  1 , José Aguayo-Arjona  3 , Ana Mariño  4 , Hortensia Álvarez  4 , Nieves Valcarce  4 , Alexandre Pérez  1 , Ezequiel Ruiz-Mateos  5 , Leonid Margolis  6 , Michael M Lederman  7 , Michael L Freeman  7
Affiliations

Elevated plasma levels of IP-10 and MIG are early predictors of loss of control among elite HIV controllers

Eva Poveda et al. Front Immunol. .

Abstract

Plasma cytokine levels were quantified among 30 persons with HIV (PWH) identified as elite controllers (15 transient controllers [studied a median of 1.38 years before losing viral control] and 15 persistent controllers). Thirty antiretroviral therapy (ART)-naive PWH, 30 ART-treated PWH with undetectable viremia, and 30 HIV-uninfected controls also were studied. Higher levels of cytokines were recognized among PWH than among controls, with EC displaying the highest levels. Elevated levels of IP-10 and MIG were identified among transient controllers as predictors of the loss of viral control. These findings offer feasible biomarkers for predicting virologic outcome and loss of control in EC.

Keywords: HIV; IP-10; MIG; elite controllers; functional cure.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision

Figures

Figure 1
Figure 1
Heatmap of the relative plasma cytokine levels. The levels of cytokines for each study group are represented as the standardized mean of each group as a comparator for each cytokine.
See this image and copyright information in PMC

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