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. 2024 Aug 29:15:1466156.
doi: 10.3389/fphar.2024.1466156. eCollection 2024.

The mechanisms and drug therapies of colorectal cancer and epigenetics: bibliometrics and visualized analysis

Siyu Tian  1 , Min Chen  2
Affiliations

The mechanisms and drug therapies of colorectal cancer and epigenetics: bibliometrics and visualized analysis

Siyu Tian et al. Front Pharmacol. .

Abstract

Background: Numerous studies have demonstrated a link between epigenetics and CRC. However, there has been no systematic analysis or visualization of relevant publications using bibliometrics.

Methods: 839 publications obtained from the Web of Science Core (WoSCC) were systematically analyzed using CiteSpace and VOSviewer software.

Results: The results show that the countries, institutions, and authors with the most published articles are the United States, Harvard University, and Ogino and Shuji, respectively. SEPT9 is a blood test for the early detection of colorectal cancer. Vitamin D and gut microbiota mediate colorectal cancer and epigenetics, and probiotics may reduce colorectal cancer-related symptoms. We summarize the specific epigenetic mechanisms of CRC and the current existence and potential epigenetic drugs associated with these mechanisms. It is closely integrated with clinical practice, and the possible research directions and challenges in the future are proposed.

Conclusion: This study reviews the current research trends and hotspots in CRC and epigenetics, which can promote the development of this field and provide references for researchers in this field.

Keywords: bibliometrics; colorectal cancer; drug therapies; epigenetics; mechanisms.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Document retrieval flow chart.
FIGURE 2
FIGURE 2
Published Trend Maps on CRC and epigenetics.
FIGURE 3
FIGURE 3
Number of publications by countries.
FIGURE 4
FIGURE 4
Intermediary centrality of countries.
FIGURE 5
FIGURE 5
Collaborative networks of countries.
FIGURE 6
FIGURE 6
Number of publications by institution.
FIGURE 7
FIGURE 7
Intermediary centrality of institutions.
FIGURE 8
FIGURE 8
Collaborative networks of institutions.
FIGURE 9
FIGURE 9
Number of publications by authors.
FIGURE 10
FIGURE 10
Collaborative networks of authors.
FIGURE 11
FIGURE 11
Cluster mapping of highly co-cited literature.
FIGURE 12
FIGURE 12
Keyword co-occurrence map of CRC and epigenetics.
FIGURE 13
FIGURE 13
Keyword cluster map of CRC and epigenetics.
FIGURE 14
FIGURE 14
Keyword clustering timeline map of CRC and epigenetics.
FIGURE 15
FIGURE 15
Keyword brusts map for CRC and epigenetics.
See this image and copyright information in PMC

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