Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2024 Oct;68(9):1215-1222.
doi: 10.1111/aas.14476. Epub 2024 Jun 22.

Perioperative association between c-reactive protein, pain catastrophizing and acute pain after total knee arthroplasty: A secondary analysis of two randomised trials

Anders H Springborg  1 , Henrik Kehlet  2   3 , Niklas I Nielsen  1 , Kirill Gromov  3   4 , Anders Troelsen  3   4 , Claus Varnum  5 , Nicolai B Foss  1   3
Affiliations
Randomized Controlled Trial

Perioperative association between c-reactive protein, pain catastrophizing and acute pain after total knee arthroplasty: A secondary analysis of two randomised trials

Anders H Springborg et al. Acta Anaesthesiol Scand. 2024 Oct.

Abstract

Background: Total knee arthroplasty is associated with an inflammatory response and high levels of pain in a subset of patients. Pain catastrophizing has been associated with acute postoperative pain. The association between these variables has not been investigated in an optimised fast-track setup including preoperative glucocorticoids. The aim of this study was, first, to investigate the correlation between the increase in postoperative c-reactive protein (CRP) and acute postoperative pain after total knee arthroplasty, and second, to investigate the correlation between the increase in CRP and preoperative pain catastrophizing.

Methods: This study is a secondary analysis of data from 119 patients participating in two randomised controlled trials. Correlation analyses were performed for preoperative CRP and CRP increase at 24 and 48 h and pain during a well-defined mobilisation at 24 and 48 h after total knee arthroplasty. Additionally, correlation analyses were performed between CRP increase and pain catastrophizing using the pain catastrophizing scale.

Results: There was no correlation between preoperative CRP or postoperative CRP increase and pain at both 24 and 48 h. Analyses were similar when separated into high and low pain catastrophizers. There was no correlation between preoperative CRP or postoperative CRP increase and pain catastrophizing.

Conclusion: There was no association between the postoperative CRP response and postoperative acute pain or pain catastrophizing in patients undergoing total knee arthroplasty in a well-defined multimodal fast-track regime including preoperative glucocorticoids. These results suggest that acute pain after knee arthroplasty is not reflected by CRP when applying preoperative glucocorticoids.

Keywords: acute postoperative pain; c‐reactive protein; inflammation; pain catastrophizing; total knee arthroplasty.

PubMed Disclaimer

References

REFERENCES

    1. Chan EY, Blyth FM, Nairn L, Fransen M. Acute postoperative pain following hospital discharge after total knee arthroplasty. Osteoarthr Cartil. 2013;21:1257‐1263.
    1. Andersen L, Gaarn‐Larsen L, Kristensen BB, Husted H, Otte KS, Kehlet H. Subacute pain and function after fast‐track hip and knee arthroplasty. Anaesthesia. 2009;64:508‐513.
    1. Ellis A, Bennett DL. Neuroinflammation and the generation of neuropathic pain. Br J Anaesth. 2013;111:26‐37.
    1. Larsson S, Thelander U, Friberg S. C‐reactive protein (CRP) levels after elective orthopedic surgery. Clin Orthop Relat Res. 1992;275:237‐242.
    1. Mehra A, Langkamer VG, Day A, Harris S, Spencer RF. C reactive protein and skin temperature post total knee replacement. Knee. 2005;12:297‐300.

Publication types

Substances

Grants and funding