Family History in Parkinson's Disease: A National Cross-Sectional Study

Federica Arienti^{1

2}, Giovanni Casazza^{3

4}, Giulia Franco^{1

2}, Giulia Lazzeri^{2

5}, Edoardo Monfrini^{1

2}, Alessandro Di Maio^{1

2}, Roberto Erro⁶, Paolo Barone⁶, Filippo Tamma⁷, Elena Caputo⁷, Maria Antonietta Volontè⁸, Laura Cacciaguerra⁸, Andrea Pilotto⁹, Alessandro Padovani⁹, Cristoforo Comi¹⁰, Luca Magistrelli⁵, Franco Valzania¹¹, Francesco Cavallieri¹¹, Laura Avanzino^{12

13}, Roberta Marchese¹³, Mariachiara Sensi¹⁴, Giorgia Carroli¹⁴, Roberto Eleopra¹⁵, Roberto Cilia¹⁵, Francesca Spagnolo¹⁶, Alessandro Tessitore¹⁷, Rosa De Micco¹⁷, Roberto Ceravolo¹⁸, Giovanni Palermo¹⁸, Maria Chiara Malaguti¹⁹, Leonardo Lopiano^{20

21}, Pierluigi Tocco²², Chiara Sorbera²³, Michele Tinazzi²⁴, Andrea Ciammola²⁵, Donatella Ottaviani²⁶, Enza Maria Valente^{27

28}, Alberto Albanese²⁹, Fabio Blandini⁴, Margherita Canesi³⁰, Angelo Antonini³¹, Miryam Carecchio³¹, Vincenza Fetoni³², Carlo Colosimo³³, Daniele Volpe³⁴, Nicola Tambasco³⁵, Giovanni Cossu³⁶, Mario Zappia³⁷; Italian Study Group on Family History in PD; Alessio Di Fonzo¹

Affiliations

¹ Foundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.
² Dino Ferrari Center, Neuroscience Section, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
³ Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
⁴ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
⁵ Gaetano Pini-CTO, Parkinson Institute, Milan, Italy.
⁶ Neuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana,", University of Salerno, Baronissi (SA), Italy.
⁷ Department of Neurology, "F. Miulli" General Hospital, Acquaviva delle Fonti, Italy.
⁸ Department of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁹ Neurology Unit and Neurobiorepository and Laboratory of Advanced Biological Markers, Department of Clinical and Experimental Sciences, University of Brescia, and Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia Hospital, Brescia, Italy.
¹⁰ Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale, Novara, Italy.
¹¹ Neurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
¹² Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy.
¹³ IRCCS Ospedale Policlinico San Martino-UOC Genetica Medica, Genoa, Italy.
¹⁴ Department of Neuroscience and Rehabilitation, Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy.
¹⁵ Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Movement Disorders Unit, Milan, Italy.
¹⁶ Neurological Department, A. Perrino's Hospital, Brindisi, Italy.
¹⁷ Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.
¹⁸ Unit of Neurology, Department of Clinical and Experimental MedicineCenter for Neurodegenerative Diseases-Parkinson's Disease and Movement Disorders, University of Pisa, Pisa, Italy.
¹⁹ Neurology Unit, Trento Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
²⁰ Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
²¹ Neurology 2 Unit, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
²² Neurology and Stroke Unit, Pescara Hospital, Pescara, Italy.
²³ Neurorehabilitation Unit IRCCS Centro Neurolesi "Bonino Pulejo," Messina, Messina, Italy.
²⁴ Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
²⁵ Department of Neurology and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.
²⁶ Neurology Unit, Rovereto Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
²⁷ Department of Molecular Medicine, University of Pavia, Pavia, Italy.
²⁸ Neurogenetics Research Center, IRCCS Mondino Foundation, Pavia, Italy.
²⁹ Department of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
³⁰ Department of Parkinson's Disease, Movement Disorders and Brain Injury Rehabilitation, Moriggia Pelascini Hospital, Gravedona, Italy.
³¹ Parkinson and Movement Disorders Unit, Center for Neurodegenerative Diseases (CENSE), Department of Neuroscience, University of Padua, Padua, Italy.
³² Neurology Department, ASST Fatebenefratelli Sacco, Milan, Italy.
³³ Department of Neurology, Santa Maria Hospital, Terni, Italy.
³⁴ Department of Neurorehabilitation, Parkinson's Disease Excellence Center, Casa di Cura Villa Margherita via Costacolonna n 1 Arcugnano, Vicenza, Italy.
³⁵ Movement Disorders Center, Neurology Department, Perugia General Hospital and University of Perugia, Perugia, Italy.
³⁶ Department of Neuroscience, Brotzu Hospital, Cagliari, Italy.
³⁷ Department GF Ingrassia, University of Catania, Catania, Italy.

PMID: 39269187
PMCID: PMC11542285
DOI: 10.1002/mdc3.14206

Multicenter Study

Family History in Parkinson's Disease: A National Cross-Sectional Study

Federica Arienti et al. Mov Disord Clin Pract. 2024 Nov.

. 2024 Nov;11(11):1434-1440.

doi: 10.1002/mdc3.14206. Epub 2024 Sep 13.

Authors

Affiliations

¹ Foundation IRCCS Ca'Granda Ospedale Maggiore Policlinico, Neurology Unit, Milan, Italy.
² Dino Ferrari Center, Neuroscience Section, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
³ Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy.
⁴ Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
⁵ Gaetano Pini-CTO, Parkinson Institute, Milan, Italy.
⁶ Neuroscience Section, Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana,", University of Salerno, Baronissi (SA), Italy.
⁷ Department of Neurology, "F. Miulli" General Hospital, Acquaviva delle Fonti, Italy.
⁸ Department of Neurology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁹ Neurology Unit and Neurobiorepository and Laboratory of Advanced Biological Markers, Department of Clinical and Experimental Sciences, University of Brescia, and Department of Continuity of Care and Frailty, ASST Spedali Civili Brescia Hospital, Brescia, Italy.
¹⁰ Department of Translational Medicine, Section of Neurology, University of Piemonte Orientale, Novara, Italy.
¹¹ Neurology Unit, Neuromotor and Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
¹² Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, Italy.
¹³ IRCCS Ospedale Policlinico San Martino-UOC Genetica Medica, Genoa, Italy.
¹⁴ Department of Neuroscience and Rehabilitation, Azienda Ospedaliera-Universitaria S. Anna, Ferrara, Italy.
¹⁵ Fondazione IRCCS Istituto Neurologico Carlo Besta, Department of Clinical Neurosciences, Movement Disorders Unit, Milan, Italy.
¹⁶ Neurological Department, A. Perrino's Hospital, Brindisi, Italy.
¹⁷ Department of Advanced Medical and Surgical Sciences, University of Campania "Luigi Vanvitelli", Caserta, Italy.
¹⁸ Unit of Neurology, Department of Clinical and Experimental MedicineCenter for Neurodegenerative Diseases-Parkinson's Disease and Movement Disorders, University of Pisa, Pisa, Italy.
¹⁹ Neurology Unit, Trento Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
²⁰ Department of Neuroscience "Rita Levi Montalcini", University of Turin, Turin, Italy.
²¹ Neurology 2 Unit, A.O.U. Città della Salute e della Scienza di Torino, Turin, Italy.
²² Neurology and Stroke Unit, Pescara Hospital, Pescara, Italy.
²³ Neurorehabilitation Unit IRCCS Centro Neurolesi "Bonino Pulejo," Messina, Messina, Italy.
²⁴ Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
²⁵ Department of Neurology and Laboratory of Neuroscience, Istituto Auxologico Italiano IRCCS, Milan, Italy.
²⁶ Neurology Unit, Rovereto Hospital, Azienda Provinciale per i Servizi Sanitari (APSS) di Trento, Trento, Italy.
²⁷ Department of Molecular Medicine, University of Pavia, Pavia, Italy.
²⁸ Neurogenetics Research Center, IRCCS Mondino Foundation, Pavia, Italy.
²⁹ Department of Neurology, IRCCS Humanitas Research Hospital, Rozzano, Italy.
³⁰ Department of Parkinson's Disease, Movement Disorders and Brain Injury Rehabilitation, Moriggia Pelascini Hospital, Gravedona, Italy.
³¹ Parkinson and Movement Disorders Unit, Center for Neurodegenerative Diseases (CENSE), Department of Neuroscience, University of Padua, Padua, Italy.
³² Neurology Department, ASST Fatebenefratelli Sacco, Milan, Italy.
³³ Department of Neurology, Santa Maria Hospital, Terni, Italy.
³⁴ Department of Neurorehabilitation, Parkinson's Disease Excellence Center, Casa di Cura Villa Margherita via Costacolonna n 1 Arcugnano, Vicenza, Italy.
³⁵ Movement Disorders Center, Neurology Department, Perugia General Hospital and University of Perugia, Perugia, Italy.
³⁶ Department of Neuroscience, Brotzu Hospital, Cagliari, Italy.
³⁷ Department GF Ingrassia, University of Catania, Catania, Italy.

PMID: 39269187
PMCID: PMC11542285
DOI: 10.1002/mdc3.14206

Abstract

Background: Family history of Parkinson's disease (PD) is a common finding in PD patients. However, a few studies have systematically examined this aspect.

Objectives: We investigated the family history of PD patients, comparing demographic and clinical features between familial PD (fPD) and sporadic PD (sPD).

Methods: A cross-sectional study enrolling 2035 PD patients was conducted in 28 Italian centers. Clinical data and family history up to the third degree of kinship were collected.

Results: Family history of PD was determined in 21.9% of patients. fPD patients had earlier age at onset than sporadic patients. No relevant differences in the prevalence of motor and nonmotor symptoms were detected. Family history of mood disorders resulted more prevalently in the fPD group.

Conclusions: fPD was found to recur more frequently than previously reported. Family history collection beyond the core family is essential to discover disease clusters and identify novel risk factors for PD.

Keywords: bipolar disorder; cognitive impairment; depression; familial and sporadic Parkinson's disease; family history; hyposmia.

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Figures

**FIG. 1**
Pie charts showing the diseases (PD, ET, Cognitive Impairment, Depressive Disorder, Bipolar Disorder) for which the family history was investigated and the percentages of certain, possible, negative, and unknown family history.

See this image and copyright information in PMC

References

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Family History in Parkinson's Disease: A National Cross-Sectional Study

Affiliations

Family History in Parkinson's Disease: A National Cross-Sectional Study

Authors

Affiliations

Abstract

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References

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MeSH terms

LinkOut - more resources

Full Text Sources

Medical