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. 2024 Dec;65(14):2190-2198.
doi: 10.1080/10428194.2024.2395458. Epub 2024 Sep 13.

A new scoring system to predict survival in elderly advanced stage Hodgkin lymphoma patients

Özgür Mehtap  1 , Tayfur Toptas  2 , Mehmet S Dal  3 , Fatma Keklik Karadag  4 , Unal Atas  5 , Güner H Özsan  6 , Nilgün Sayınalp  7 , Guray Saydam  4 , Mehmet Ali Uçar  8 , Hakkı Onur Kırkızlar  9 , Ozan Salim  5 , Atakan Tekinalp  10 , Fahir Özkalemkaş  11 , Funda Pepedi  8 , Olga M Akay  12 , Emrah Kılıçaslan  13 , Semra Paydas  8 , Sinem Civriz Bozdağ  12 , Mehmet Yılmaz  14 , Volkan Karakus  15 , Fatma Gecgel Arikan  2 , Tahir Darçın  3 , Elcin Erdogan  6 , Erkin Cinar  7 , Vildan Gürsoy  11 , Salih S Durusoy  14 , Elif Birtaş Ateşoğlu  16 , Anıl Tombak  17 , Nurhilal Büyükkurt  18 , Muhit Özcan  19 , Fevzi Altuntaş  3 , Işık Kaygusuz Atagündüz  2 , Burhan Ferhanoglu  12
Affiliations

A new scoring system to predict survival in elderly advanced stage Hodgkin lymphoma patients

Özgür Mehtap et al. Leuk Lymphoma. 2024 Dec.

Abstract

Predictive prognostic scoring (PS) systems are not primarily applicable to elderly patients with classical Hodgkin lymphoma (cHL). The objective of this study was to develop a PS system for these patients. The derivation cohort (DC) was utilized for model development, consisting of 97 variables. The resulting algorithm was named as Hodgkin's Lymphoma Early Death in the Elderly within 12 months (HEDEL12). Internal and external validation cohorts (IVC and EVC) were employed for validation. A total of 286 patients were evaluated retrospectively. In DC 38 of 178 patients died within the first 12 months and overall survival (OS) at 12-month was 78.6%. Independent predictors of HEDEL12 were female sex, low albumin levels (<3.5 g/dL), and ECOG scores 2-4. According to HEDEL12 scores 0-1, OS at 12- months were 89.8% and 91.0% for IVC and EVC, respectively. The HEDEL12 scoring is useful in predicting the survival of advanced-stage cHL patients.

Keywords: Elderly hodgkin lymphoma; advanced stage; prognostic scoring.

Plain language summary

Predictive prognostic scoring (PS) systems are not applicable to elderly patients with classical Hodgkin lymphomaFemale sex, low albumin levels (<3.5 g/dL), and ECOG scores 2-4 are independent predictors of survival in older advanced stage cHL patients.

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