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Review
. 2025 Apr;145(4):780-789.
doi: 10.1016/j.jid.2024.07.029. Epub 2024 Sep 14.

Nucleic Acid Therapy for the Skin

Andreas C Chai  1 , Daniel J Siegwart  2 , Richard C Wang  3
Affiliations
Review

Nucleic Acid Therapy for the Skin

Andreas C Chai et al. J Invest Dermatol. 2025 Apr.

Abstract

Advances in sequencing technologies have facilitated the identification of the genes and mechanisms for many inherited skin diseases. Although targeted nucleic acid therapeutics for diseases in other organs have begun to be deployed in patients, the goal of precise therapeutics for skin diseases has not yet been realized. First, we review the current and emerging nucleic acid-based gene-editing and delivery modalities. Next, current and emerging viral and nanoparticle vehicles for the delivery of gene therapies are reviewed. Finally, specific skin diseases that could benefit optimally from nucleic acid therapies are highlighted. By adopting the latest technologies and addressing specific barriers related to skin biology, nucleic acid therapeutics have the potential to revolutionize treatments for patients with skin disease.

Keywords: Drug development; Gene therapy; Genetic diseases; Genetics; Genodermatoses.

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Conflict of interest statement

CONFLICT OF INTEREST

D.J.S. discloses financial interests in ReCode Therapeutics, Signify Bio, Jumble Therapeutics, and Tome Biosciences. The remaining authors state no conflict of interest.

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