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. 2024 Dec;33(12):3421-3433.
doi: 10.1007/s11136-024-03784-z. Epub 2024 Sep 13.

The association of the comorbidity status of metabolic syndrome and cognitive dysfunction with health-related quality of life

Yi-Hsuan Lin  1   2   3 , Hsiao-Ting Chang  4   5 , Yen-Feng Wang  2   6 , Jong-Ling Fuh  2   6 , Shuu-Jiun Wang  2   6 , Harn-Shen Chen  2   7 , Sih-Rong Li  3 , Ming-Hwai Lin  2   3 , Tzeng-Ji Chen  2   3   8   9 , Shinn-Jang Hwang  2   3   10
Affiliations

The association of the comorbidity status of metabolic syndrome and cognitive dysfunction with health-related quality of life

Yi-Hsuan Lin et al. Qual Life Res. 2024 Dec.

Abstract

Purpose: Both metabolic syndrome (MetS) and cognitive dysfunction impair health-related quality of life (HRQOL). This study aims to determine whether individuals experiencing both MetS and cognitive dysfunction have lower HRQOL.

Methods: This cross-sectional study enrolled 567 participants who attended outpatient clinics at a medical center in northern Taiwan. MetS was diagnosed according to the modified criteria for the Asian population. Cognitive function was categorized as normal, mild cognitive dysfunction, and advanced cognitive dysfunction according to the score of the Montreal Cognitive Assessment, Taiwanese version. HRQOL was assessed using the SF-36v2® Health Survey (SF-36v2). The associations of the comorbidity status of MetS and cognitive dysfunction with HRQOL were analyzed using linear regression models, adjusting for age, sex, marital status, education level, income groups, and activities of daily living.

Results: Out of 567 participants, 33 (5.8%) had MetS with mild cognitive dysfunction, and 34 (6.0%) had MetS with advanced cognitive dysfunction. Participants with both MetS and advanced cognitive dysfunction exhibited the lowest scores in the physical component summary and almost all scales of HRQOL. MetS exacerbated the inverse association between mild cognitive dysfunction and the mental component summary. For those with MetS, the scores on scales of role physical, bodily pain, vitality, and social functioning worsened as cognitive function deteriorated (all Ptrend<0.05).

Conclusion: As the severity of comorbidity between MetS and cognitive dysfunction varies, patients exhibited poorer performance in different aspects of HRQOL. Future research is needed to find solutions to improve HRQOL for patients with both MetS and cognitive dysfunction.

Keywords: Cognitive dysfunction; Health-related quality of life; Metabolic syndrome; SF-36 Health Survey; Taiwan.

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Conflict of interest statement

Declarations. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Research Ethics Committee of Taipei Veterans General Hospital, Taipei, Taiwan, on May 9, 2022 (Protocol Code: 2020-06-001 A). Consent to participate: All participants in this study provided written informed consent before participating in the research. Competing interests: The authors declare that they have no conflict of interest.

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