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Review
. 2024 Dec:256:103217.
doi: 10.1016/j.autneu.2024.103217. Epub 2024 Sep 7.

The role of peripheral venous distension reflex in regulating hemodynamics: mini review

Takuto Hamaoka  1 , Lawrence I Sinoway  1 , Jian Cui  2
Affiliations
Review

The role of peripheral venous distension reflex in regulating hemodynamics: mini review

Takuto Hamaoka et al. Auton Neurosci. 2024 Dec.

Abstract

Significant volume is pooled in veins in humans and the amount is dramatically altered by various physiological stresses and diseases. Several animal and human studies demonstrated that limb venous distension evoked significant increases in blood pressure and sympathetic nerve activity (venous distension reflex, VDR). VDR has attracted much attention because of its potential to explain the still unknown mechanism of autonomic dysfunction in several diseases, which would lead to a new treatment approach. This mini review discusses accumulated evidence of VDR at this point and what should be investigated in the future to apply the current understanding of VDR in clinical practice.

Keywords: Autonomic nerve function; Blood pressure; Muscle sympathetic nerve activity; Peripheral vein; Venous distension reflex.

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Conflict of interest statement

Declaration of competing interest The authors declare that there are no competing interests associated with the manuscript.

References

    1. Ali YS, Daamen N, Jacob G, Jordan J, Shannon JR, Biaggioni I, Robertson D 2000. Orthostatic intolerance: a disorder of young women. Obstet Gynecol Surv 55, 251–259. - PubMed
    1. Andres KH, von Düring M, Schmidt RF 1985. Sensory innervation of the Achilles tendon by group III and IV afferent fibers. Anat Embryol (Berl) 172, 145–156. - PubMed
    1. Andrews CJ, Andrews WH, Orbach J 1972. A sympathetic reflex elicited by distension of the mesenteric venous bed. J Physiol 226, 119–131. - PMC - PubMed
    1. Arcelus J, Caprini J, Traverso C, Size G, Hasty J 1993. The role of elastic compression stockings in prevention of venous dilatation induced by a reverse Trendelenburg position. Phlebology 8, 111–115.
    1. Armstrong PW, Walker DC, Burton JR, Parker JO 1975. Vasodilator therapy in acute myocardial infarction. A comparison of sodium nitroprusside and nitroglycerin. Circulation 52, 1118–1122. - PubMed

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