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. 1985 May;61(715):391-4.
doi: 10.1136/pgmj.61.715.391.

Effect of propranolol on thyroid homeostasis of healthy volunteers

M R Wilkins, J A Franklyn, K L Woods, M J Kendall

Effect of propranolol on thyroid homeostasis of healthy volunteers

M R Wilkins et al. Postgrad Med J. 1985 May.

Abstract

The effect of propranolol on thyroid status was investigated by administering the drug in 2 therapeutic doses (80 mg b.d. and 120 mg b.d.) to 8 healthy volunteers and serially measuring total and free thyroid hormones and their major binding protein. Mean free T3 fell by 1.2 pmol/l (P less than 0.05) whilst mean free T4 and mean rT3 rose by 3.3 pmol/l (P less than 0.01) and 0.16 nmol/l (P less than 0.01) respectively. Mean thyroxine binding globulin (TBG) fell by 1.2 mg/l (P less than 0.001). Despite the change in free hormone levels there was no significant change in TSH. For the first time the effect of propranolol on circulating thyroid hormones and binding proteins in healthy subjects is apparent within one study. The biological significance of the change in free hormone levels is discussed.

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References

    1. Anal Biochem. 1966 Apr;15(1):45-52 - PubMed
    1. Clin Endocrinol (Oxf). 1977 Jun;6(6):405-10 - PubMed
    1. Clin Pharmacol Ther. 1977 Dec;22(6):864-7 - PubMed
    1. Ann Clin Biochem. 1977 Nov;14(6):330-4 - PubMed
    1. Clin Endocrinol (Oxf). 1978 Jul;9(1):67-72 - PubMed