Nutraceuticals in Pregnancy: A Special Focus on Probiotics

doi:10.3390/ijms25179688

Review

. 2024 Sep 7;25(17):9688.

doi: 10.3390/ijms25179688.

Nutraceuticals in Pregnancy: A Special Focus on Probiotics

Angelica Perna¹, Noemi Venditti^{1

2}, Francesco Merolla¹, Sabato Fusco¹, Germano Guerra¹, Stefano Zoroddu³, Antonio De Luca⁴, Luigi Bagella^{3

5}

Affiliations

¹ Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via F. De Sanctis, 86100 Campobasso, Italy.
² UO Laboratory Analysis, Responsible Research Hospital, Largo Agostino Gemelli, 1, 86100 Campobasso, Italy.
³ Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy.
⁴ Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, University of Campania "Luigi Vanvitelli", Via Costantinopoli 16, 80138 Naples, Italy.
⁵ Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.

PMID: 39273635
PMCID: PMC11395456
DOI: 10.3390/ijms25179688

Review

Nutraceuticals in Pregnancy: A Special Focus on Probiotics

Angelica Perna et al. Int J Mol Sci. 2024.

. 2024 Sep 7;25(17):9688.

doi: 10.3390/ijms25179688.

Authors

Angelica Perna¹, Noemi Venditti^{1

2}, Francesco Merolla¹, Sabato Fusco¹, Germano Guerra¹, Stefano Zoroddu³, Antonio De Luca⁴, Luigi Bagella^{3

5}

Affiliations

¹ Department of Medicine and Health Sciences "Vincenzo Tiberio", University of Molise, Via F. De Sanctis, 86100 Campobasso, Italy.
² UO Laboratory Analysis, Responsible Research Hospital, Largo Agostino Gemelli, 1, 86100 Campobasso, Italy.
³ Department of Biomedical Sciences, University of Sassari, Viale San Pietro 43/b, 07100 Sassari, Italy.
⁴ Department of Mental and Physical Health and Preventive Medicine, Section of Human Anatomy, University of Campania "Luigi Vanvitelli", Via Costantinopoli 16, 80138 Naples, Italy.
⁵ Sbarro Institute for Cancer Research and Molecular Medicine, Centre for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.

PMID: 39273635
PMCID: PMC11395456
DOI: 10.3390/ijms25179688

Abstract

The placenta is crucial to fetal development and performs vital functions such as nutrient exchange, waste removal and hormone regulation. Abnormal placental development can lead to conditions such as fetal growth restriction, pre-eclampsia and stillbirth, affecting both immediate and long-term fetal health. Placental development is a highly complex process involving interactions between maternal and fetal components, imprinted genes, signaling pathways, mitochondria, fetal sexomes and environmental factors such as diet, supplementation and exercise. Probiotics have been shown to make a significant contribution to prenatal health, placental health and fetal development, with associations with reduced risk of preterm birth and pre-eclampsia, as well as improvements in maternal health through effects on gut microbiota, lipid metabolism, vaginal infections, gestational diabetes, allergic diseases and inflammation. This review summarizes key studies on the influence of dietary supplementation on placental development, with a focus on the role of probiotics in prenatal health and fetal development.

Keywords: nutraceuticals; placenta; placenta development; pre-eclampsia; probiotics.

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Conflict of interest statement

All the authors confirm that they have received guidance on competing interests and none have any competing interests in the manuscript. The authors declare no conflicts of interest.

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References

1. Cindrova-Davies T., Sferruzzi-Perri A.N. Human placental development and function. Semin. Cell Dev. Biol. 2022;131:66–77. doi: 10.1016/j.semcdb.2022.03.039. - DOI - PubMed
1. Macnab W.R. Functions of the placenta. Anaesth. Intensive Care Med. 2022;23:344–346. doi: 10.1016/j.mpaic.2022.03.003. - DOI
1. Virdis P., Migheli R., Galleri G., Fancello S., Cadoni M.P.L., Pintore G., Petretto G.L., Marchesi I., Fiorentino F.P., di Francesco A., et al. Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line. Tumour Biol. 2020;42:1010428319901061. doi: 10.1177/1010428319901061. - DOI - PubMed
1. Verma U., Verma N. The Placenta: Development, Function and Diseases. Nova Science Publishers; Hauppauge, NY, USA: 2013. An overview of development, function, and diseases of the placenta; pp. 1–30.
1. Panja S., Paria B.C. Advances in Anatomy Embryology and Cell Biology. Volume 234. Springer; Cham, Switzerland: 2021. Development of the Mouse Placenta; pp. 205–221. - PMC - PubMed

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[1] Cindrova-Davies T., Sferruzzi-Perri A.N. Human placental development and function. Semin. Cell Dev. Biol. 2022;131:66–77. doi: 10.1016/j.semcdb.2022.03.039. - DOI - PubMed

[2] Cindrova-Davies T., Sferruzzi-Perri A.N. Human placental development and function. Semin. Cell Dev. Biol. 2022;131:66–77. doi: 10.1016/j.semcdb.2022.03.039. - DOI - PubMed

[3] Macnab W.R. Functions of the placenta. Anaesth. Intensive Care Med. 2022;23:344–346. doi: 10.1016/j.mpaic.2022.03.003. - DOI

[4] Macnab W.R. Functions of the placenta. Anaesth. Intensive Care Med. 2022;23:344–346. doi: 10.1016/j.mpaic.2022.03.003. - DOI

[5] Virdis P., Migheli R., Galleri G., Fancello S., Cadoni M.P.L., Pintore G., Petretto G.L., Marchesi I., Fiorentino F.P., di Francesco A., et al. Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line. Tumour Biol. 2020;42:1010428319901061. doi: 10.1177/1010428319901061. - DOI - PubMed

[6] Virdis P., Migheli R., Galleri G., Fancello S., Cadoni M.P.L., Pintore G., Petretto G.L., Marchesi I., Fiorentino F.P., di Francesco A., et al. Antiproliferative and proapoptotic effects of Inula viscosa extract on Burkitt lymphoma cell line. Tumour Biol. 2020;42:1010428319901061. doi: 10.1177/1010428319901061. - DOI - PubMed

[7] Verma U., Verma N. The Placenta: Development, Function and Diseases. Nova Science Publishers; Hauppauge, NY, USA: 2013. An overview of development, function, and diseases of the placenta; pp. 1–30.

[8] Verma U., Verma N. The Placenta: Development, Function and Diseases. Nova Science Publishers; Hauppauge, NY, USA: 2013. An overview of development, function, and diseases of the placenta; pp. 1–30.

[9] Panja S., Paria B.C. Advances in Anatomy Embryology and Cell Biology. Volume 234. Springer; Cham, Switzerland: 2021. Development of the Mouse Placenta; pp. 205–221. - PMC - PubMed

[10] Panja S., Paria B.C. Advances in Anatomy Embryology and Cell Biology. Volume 234. Springer; Cham, Switzerland: 2021. Development of the Mouse Placenta; pp. 205–221. - PMC - PubMed

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Nutraceuticals in Pregnancy: A Special Focus on Probiotics

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Nutraceuticals in Pregnancy: A Special Focus on Probiotics

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