Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Sep 9;13(17):5330.
doi: 10.3390/jcm13175330.

Predictive Value of Neutrophil-Lymphocyte Ratio and Other Inflammation Indices in Febrile Seizures in Children

Yakup Söğütlü  1 , Uğur Altaş  2
Affiliations

Predictive Value of Neutrophil-Lymphocyte Ratio and Other Inflammation Indices in Febrile Seizures in Children

Yakup Söğütlü et al. J Clin Med. .

Abstract

Objective: There is increasing evidence for the effect of inflammation on the etiology of febrile seizure (FS) patients. We aimed to investigate the role of easily accessible inflammatory markers such as the neutrophil-lymphocyte ratio (NLR), systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), neutrophil-lymphocyte-platelet ratio (NLPR), and pan-immune-inflammation value (PIV) in febrile seizure. Methods: A total of 300 children, including 100 with febrile convulsions (FS), 100 febrile controls (FCs), and 100 healthy controls (HCs), were included in this retrospective study. The FS group was compared with the FC and HC groups in terms of these inflammatory indexes. Results: Between the FS group and the FC group, the neutrophil count was significantly higher in the FS group (p = 0.001) and the lymphocyte count was significantly lower (p < 0.001). The NLR (p < 0.001), SII (p < 0.001), SIRI (p < 0.001), NLPR (p < 0.001), and PIV (p < 0.001) were significantly higher in the FS group than in both the FC and healthy control groups. The optimal cut-off values for predicting FS in febrile conditions were 3.59> for NLR, >870.47 for SII, >1.96 for SIRI, 0.96> for NLPR, and >532.75 for PIV. Conclusions: The inflammatory indices are inexpensive, easily accessible hematological markers that can contribute to the diagnosis of FS.

Keywords: febrile seizure; inflammation; neutrophil–lymphocyte–platelet ratio; pan-immune-inflammation value; systemic immune-inflammation index; systemic inflammation response index.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Participants included in the study.
Figure 2
Figure 2
Receiver operating curve results of inflammatory indices for the distinction between FS and FC and for the distinction between FS and HC. NLR: neutrophil/lymphocyte ratio. SIRI: systemic inflammation response index. SII: systemic immune-inflammation index. PIV: pan-immune-inflammation value. NLPR: neutrophil/lymphocyte/platelet ratio.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Han M.J., Heo J.H., Hwang J.S., Jang Y.-T., Lee M., Kim S.J. Incidence of Febrile Seizures in Children with COVID-19. J. Clin. Med. 2023;12:1076. doi: 10.3390/jcm12031076. - DOI - PMC - PubMed
    1. Xixis K.L., Samanta D., Smith T., Keenaghan M. Febrile Seizure. [(accessed on 3 September 2024)]; Available online: https://www.ncbi.nlm.nih.gov/books/NBK448123/
    1. Eilbert W., Chan C. Febrile seizures: A review. J. Am. Coll. Emerg. Physicians Open. 2022;3:e12769. doi: 10.1002/emp2.12769. - DOI - PMC - PubMed
    1. Kwon A., Kwak B.O., Kim K., Ha J., Kim S.J., Bae S.H., Son J.S., Kim S.N., Lee R. Cytokine levels in febrile seizure patients: A systematic review and meta-analysis. Seizure. 2018;59:5–10. doi: 10.1016/j.seizure.2018.04.023. - DOI - PubMed
    1. Moldovan F. Sterile Inflammatory Response and Surgery-Related Trauma in Elderly Patients with Subtrochanteric Fractures. Biomedicines. 2024;12:354. doi: 10.3390/biomedicines12020354. - DOI - PMC - PubMed

LinkOut - more resources