Observational Study
doi: 10.1016/j.hpb.2024.07.407.
Epub 2024 Jul 16.
Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma
Jens Smits
1
, Steven Chau
2
, Sinéad James
1
, Remon Korenblik
1
, Madita Tschögl
3
, Pieter Arntz
4
, Jan Bednarsch
5
, Luis Abreu de Carvalho
6
, Olivier Detry
7
, Joris Erdmann
4
, Thomas Gruenberger
3
, Laurens Hermie
8
, Ulf Neumann
9
, Per Sandström
10
, Robert Sutcliffe
11
, Alban Denys
12
, Emmanuel Melloul
13
, Maxime Dewulf
14
, Christiaan van der Leij
15
, Ronald M van Dam
16
; EuroLVD and DRAGON Trials Collaborative
Collaborators,
Affiliations
Collaborators
-
EuroLVD and DRAGON Trials Collaborative:
Patrick Chevallier 17 , Stephen Wigmore 18 , Timothy Newhook 19 , Jean-Nicolas Vauthey 19 , Riccardo Memeo 20 , Bobby Vm Dasari 21 , Eva Braunwarth 22 , Luca Aldrighetti 23 , Esteban Cugat Andorrà 24 , Pieter Arntz 25 , Bulent Arslan 26 , Laurens van Baardewijk 27 , Ivan Baclija 28 , Chad Ball 29 , Louise Barbier 30 , Jan Bednarsch 31 , Marc Bemelmans 32 , Clare Bent 33 , Frans van den Bergh 34 , Kevin Billingsley 35 , Christoph Binkert 36 , Bergthor Björnsson 37 , Marieke T de Boer 38 , Reinoud P H Bokkers 39 , Diederick de Boo 40 , Francisco Javier Garcia Borobia 41 , Dries Braat 42 , David Breen 43 , Stefan Breitenstein 44 , Karine Brousseau 45 , Ruther Bruijnen 46 , Philipp Bruners 47 , Christiane Bruns 48 , Alexander Bunck 49 , Mark Burgmans 50 , Alberta Cappelli 51 , Ulrik Carling 52 , Luis Abreu de Carvalho 53 , Charles Cha 54 , Benjamin Chan 55 , Belinda Chand 40 , Thiery Chapelle 56 , Franceso De Cobelli 57 , Laurent Coubeau 58 , Eva Criado 59 , Daniel Croagh 60 , Mathieu D'Hondt 61 , Ronald van Dam 32 , Steven Olde Damink 62 , Rob Davis 63 , Martin Delle 64 , Alban Denys 65 , Fabrice Deprez 66 , Olivier Detry 67 , Maxime Dewulf 62 , Alexandra Dili 68 , Matthew Dixon 69 , Rafael Díaz-Nieto 70 , Joris I Erdmann 71 , Rukshan Fernando 72 , Jaume Codina Font 73 , Suomi Fouraschen 38 , Olivier François 74 , Åsmund A Fretland 75 , Yilian Fundora 76 , Sameer Gadani 77 , Steven Gallinger 78 , Alexandra Geleabert 79 , Laurent Gerard 80 , Josep Guitart Giménez 81 , Paul Gobardhan 82 , Pierre Goffette 83 , Lukasz Filip Grochola 84 , Thomas Gruenberger 85 , Dirk Grünhagen 86 , Felice Guiliante 87 , Fernando Gómez 88 , Jeroen Hagendoorn 89 , John Hammond 90 , Margot Heijmans 91 , Jan Heil 92 , Daniel Heise 31 , Laurens Hermie 93 , Eric Herrero 94 , Gebriel Hess 95 , Sam Heye 96 , Martin Hoffmann 97 , Roberto Iezzi 98 , Farshad Imani 99 , Sinead James 32 , Thomas Jardinet 100 , Kunal Joshi 101 , Elio Jovine 102 , Jennifer Kalil 103 , Paul Karanicolas 104 , Geert Kazemier 25 , Lars Kern 105 , Peter Kingham 106 , Darren Klass 107 , Bas Groot Koerkamp 108 , Otto Kollmar 109 , Remon Korenblik 62 , Choon Kwon 110 , Céline Lambrecht 111 , Sven Lang 112 , Laura-Ann 113 , Wouter Leclercq 91 , Christiaan van der Leij 114 , Richard Lindsay 115 , Santiago Lopez-Ben 116 , Valerio Lucidi 117 , Jordi Navinés López 118 , Andrew Macdonald 119 , David C Madoff 120 , George Markose 121 , Gilbert Maroune 122 , Guillaume Martel 123 , Ernesto Santos Martin 124 , Homoyon Mehrzad 125 , Martijn Meijerink 126 , Emmanuel Melloul 127 , Nouredin Messaoudi 128 , Peter Metrakos 129 , Sachin Modi 43 , Nicola Montanari 130 , Jaume Sampere Moragues 131 , Amol Mujoomdar 132 , Ulf Neumann 31 , Jelmer Oor 133 , Patroklos Pappas 69 , Kay Pieterman 134 , John Primrose 135 , Xudong Qu 136 , Francesca Ratti 137 , Fourat Ridouani 138 , Inne H M Borel Rinkes 89 , Margarida Casellas I Robert 139 , Steffen Ross 140 , Leyo Ruo 141 , Stephen Ryan 142 , Aysun Salik 143 , Per Sandström 37 , Jonas Santol 144 , Luis Sarría 145 , Benedikt Schaarschmidt 146 , Erik Schadde 147 , Marc Schiesser 147 , Moritz Schmelzle 148 , Nico Seeger 105 , Maja Segedi 107 , Matteo Serenari 149 , Gregory Sergeant 150 , Alejandro Serrablo 151 , Sorina Simon 114 , Anton Skaro 152 , Maarten Smits 153 , Jens Smits 154 , Andreas Snitzbauer 92 , Zahir Soonawalla 155 , Ernesto Sparrelid 156 , Elmar Spuentrup 157 , Gregor Stavrou 158 , Robert Sutcliffe 101 , Rutger-Jan Swijnenburg 25 , Ilario Tancredi 159 , Jordan C Tasse 26 , Madita Tschögl 144 , Venkatesha Udupa 155 , David A Valenti 160 , David Vass 161 , Ariadne Lisa van der Velden 114 , Thomas Vogl 162 , Frank Wacker 163 , Xiaoying Wang 164 , Jürgen Weitz 165 , Steven White 90 , Rizky Widyaningsih 113 , Jean-François De Wispelaere 166 , Ijsbrand Zijlstra 167
Affiliations
- 1 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands; GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands.
- 2 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands.
- 3 Department of Surgery, HPB Centre Vienna Health Network, Clinic Favoriten, Wienerbergstraße 13, 1100, Vienna, Austria.
- 4 Department of Surgery, Amsterdam University Medical Centre Location AMC, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.
- 5 Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
- 6 Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
- 7 Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, Avenue de l'Hôpital 1, 4000, Liège, Belgium.
- 8 Department of Vascular and Interventional Radiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
- 9 Department of General, Visceral and Transplantation Surgery, Essen University Hospital, Hufelandstraße 55, 45147, Essen, Germany.
- 10 Department of Surgery in Linköping and Biomedical and Clinical Sciences, Linköping University, Universitetssjukhuset, 581 85 Linköping, Sweden.
- 11 Department of Surgery, Queen Elizabeth Hospital Birmingham NHS, Mindelsohn Way, Birmingham, B15 2GW, United Kingdom.
- 12 Department of Radiology and Interventional Radiology, CHUV University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
- 13 Department of Visceral Surgery, Lausanne University Hospital and University of Lausanne, CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
- 14 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands. Electronic address: maxime.dewulf@mumc.nl.
- 15 GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands.
- 16 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands; GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: r.van.dam@mumc.nl.
- 17 Department of Diagnosis and Interventional Imaging, University Hospital of Nice, France.
- 18 Clinical Surgery, University of Edinburgh & Royal Infirmary of Edinburgh, Scotland.
- 19 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
- 20 Department of Hepato-Pancreatic-Biliary Surgery, Miulli Hospital, Bari, Italy.
- 21 Department of Hepatobiliary and Pancreatic Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom.
- 22 Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
- 23 Department of Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milano, Italy.
- 24 Department of Hepato-Pancreato-Biliary Surgery, Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona, Spain, Spain.
- 25 Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, The Netherlands.
- 26 Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, United States.
- 27 Department of Radiology, Maxima Medical Center, Eindhoven, Netherlands.
- 28 department of Radiology, Kaiser Franz Josef Hospital, Vienna, Austria.
- 29 Department of Surgery, Foothills Medical Centre, Calgary, Alberta, Canada.
- 30 Department of Surgery, Auckland District Health Board, Auckland, New Zealand.
- 31 Department of Surgery, University Hospital Aachen, Aachen, Germany.
- 32 Department of Surgery, Maastricht University Medical Center+, Maastricht, Netherlands.
- 33 RBCH, Royal Bournemouth and Christchurch Hospital, Bournemouth, United Kingdom.
- 34 Department of Radiology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
- 35 Department of Surgery, Yale University School of Medicine, New Haven, USA.
- 36 Department of Radiology, Kantonsspital (KSW) Winterthur, Winterthur, Switzerland.
- 37 Department of surgery and Dept of biomedical and clinical sciences, University hospital of Linköping, Linköping, Sweden.
- 38 Hepato-Pancreatico-Biliary Surgery and Liver Transplantation, Department of Surgery, University Medial Center Groningen, Groningen, Netherlands.
- 39 Department of Radiology, University Medical Center Groningen, Groningen, Netherlands.
- 40 Department of Radiology, Monash Health, Clayton, Australia.
- 41 Department of surgery, Parc Tauli Hospital, Sabadell, Spain.
- 42 Department of Surgery, Leids Universitair Medisch Centrum, Leiden, Netherlands.
- 43 Department of Radiology, University Hospital Southampton, Southampton, United Kingdom.
- 44 Department of Surgery, Kantonsspital (KSW) Winterthur, Winterthur, Switzerland.
- 45 Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Canada.
- 46 Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
- 47 Department of Radiology, University Hospital Aachen, Aachen, Germany.
- 48 Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
- 49 Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
- 50 Department of Radiology, Leids Universitair Medisch Centrum, Leiden, Netherlands.
- 51 Department of Radiology, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
- 52 Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
- 53 Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, Ghent, Belgium.
- 54 Department of Surgery, Yale school of Medicine, New Haven, United States.
- 55 Department of Surgery, Univeristy Hospital Aintree, Liverpool, United Kingdom.
- 56 Department of Hepatobiliary and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
- 57 Department of Radiology, IRCCS Ospedale San Raffale, Milano, Italy.
- 58 Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
- 59 Interventional Radiology Unit, UDIAT-Centre Diagnòstic, Hospital Universitario Parc Tauli Sabadell, Medicine Department Universidad Autónoma de Barcelona, Barcelona, Spain.
- 60 Department of Surgery, Monash Health, Clayton, Australia.
- 61 Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium.
- 62 Maastricht University Medical Center+, Maastricht, Netherlands.
- 63 Department of Radiology, Aintree University Hospital, Liverpool, United Kingdom.
- 64 Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.
- 65 Department of Radiology and Interventional Radiology, CHUV University of Lausanne, Lausanne, Switzerland.
- 66 Department of Radiology, CHU- UcLouvain-Namur, Yvoir, Belgium.
- 67 Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, Belgium.
- 68 Department of Surgery, CHU-UCL Namur site Godine, Namur, Belgium.
- 69 Department of Surgery, Rush University Medical Center, Chicago, USA.
- 70 Department of Surgery, Aintree University Hospital, Liverpool, United Kingdom.
- 71 Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdan, Netherlands.
- 72 Department of Radiology, Auckland District Health Board, Auckland, New Zealand.
- 73 Department of Interventional Radiology, University Hospital Dr. Josep Trueta, Girona, Spain.
- 74 Department of Medical Imaging, AZ Groeninge, Kortrijk, Belgium.
- 75 Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
- 76 Department of Surgery, Clínic Barcelona, Barcelona, Spain.
- 77 Section of Vascular and Interventional Radiology, Imaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
- 78 Department of Surgery, University Health Network, Toronto, Canada.
- 79 Department of Radiology, Hospital Parc Taulí de Sabadell, Sabadell, Spain.
- 80 Departement of Radiology, CHU Liege, Belgium.
- 81 Department of Radiology, University Hospital Mútua Terassa, Terassa, Spain.
- 82 Deparment of Surgery, Amphia, Breda, Netherlands.
- 83 Department of Radiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
- 84 Department of Surgery, Kantonsspital (KSW) Winterthur, Winterthur, Switzerland; Department of Visceral and Thoracic Surgery, Kantonsspital Winterthur, Winterthur, Switzerland.
- 85 Department of Surgery, Kaiser Franz Josef Hospital, Vienna, Austria.
- 86 Department of Surgical Oncology, Erasmus Medical Center, Cancer Institute, Rotterdam, Netherlands.
- 87 Department of Hepato-Biliary Surgery, Catholic University Rome, Rome, Italy.
- 88 Department of Radiology, Clínic de Barcelona, Barcelona, Spain.
- 89 Department of Surgery, UMC Utrecht Cancer Center, Utrecht, Netherlands.
- 90 Department of Surgery, The Newcastle upon Tyne Hospitals, Newcastle, United Kingdom.
- 91 Department of Surgery, Maxima Medical Center, Eindhoven, Netherlands.
- 92 Department of General, Visceral, Transplant and Thoracic Surgery, Goethe-University Frankfurt, University Hospital Frankfurt, Germany.
- 93 Department of Vascular and Interventional Radiology, Ghent University Hospital, Ghent, Belgium.
- 94 Department of Surgery, University Hospital Mútua Terassa, Terassa, Spain.
- 95 Clarunis, University Centre for Gastrointestinal and Liver Diseases, Basel, Switzerland.
- 96 Department of Radiology, Jessa Ziekenhuis, Hasselt, Belgium.
- 97 Department of Radiology, St. Clara hospital, Basel, Switzerland.
- 98 Department of Radiology, Agostino Gemelli University Hospital Rome, Rome, Italy.
- 99 Department of Radiology, Amphia Breda, Netherlands.
- 100 Department of Radiology, Antwerp University Hospital, Edegem, Belgium.
- 101 Department of General Surgery, University Hospital Birmingham, Birmingham, United Kingdom.
- 102 Department of Surgery, Maggiore Hospital, Bologna, Italy.
- 103 McGill University Medical Center, Montreal, Canada.
- 104 Division of General Surgery, Sunnybrook Health Sciences Centre, Canada.
- 105 Department of Visceral and Thoracic Surgery, Kantonsspital Winterthur, Winterthur, Switzerland.
- 106 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States.
- 107 Department of Surgery, Vancouver General Hospital, Vancouver, Canada.
- 108 Department of Surgery, Erasmus Medisch Centrum, Rotterdam, The Netherlands.
- 109 Department of Surgery, Clarunis University Hospital, Basel, Switzerland.
- 110 Department of Hepato-Pancreato-Biliary/Liver Transplant Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
- 111 Department of Abdominal Surgery and Transplantation, University of Liege, CHU Liege, Liege, Belgium.
- 112 Department of General, Visceral and Transplantation Surgery, Essen University Hospital, Essen, Germany.
- 113 Department of General, Visceral and Thoracic Surgery, Surgical Oncology, Klinikum Saarbruecken, Saarbruecken, Germany.
- 114 Department of Radiology, Maastricht University Medical Center+, Maastricht, Netherlands.
- 115 Department of Radiology, Belfast Health and Social Care Trust, Belfast, United Kingdom.
- 116 Department of Hepato-Biliary and Pancreatic Surgery, University Hospital Dr. Josep Trueta, Griona, Spain.
- 117 Department of Abdominal Surgery, Clinic of Hepato-Biliary Surgery and Liver Transplantation, Erasme University Hospital - ULB, Brussels, Belgium.
- 118 Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona.
- 119 Department of Radiology, Oxford University Hospitals, Oxford, United Kingdom.
- 120 Department of Radiology, Yale school of Medicine, New Haven, United States.
- 121 Department of Radiology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
- 122 Department of Vascular and Interventional Radiology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada.
- 123 Department of Surgery, Ottawa hospital, Ottawa, Canada.
- 124 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.
- 125 Deparment of Imaging and Interventional Radiology, Queen Elisabeth Hospital Birmingham, University Hospital Birmingham, Birmingham, United Kingdom.
- 126 Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center VUMC, Amsterdam, Netherlands.
- 127 Department of Visceral Surgery, Lausanne University Hospital and University of Lausanne, CHUV, Lausanne, Switzerland.
- 128 Department of Surgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.
- 129 Department of Surgery, McGill University Hospital, Montreal, Canada.
- 130 Department of Radiology, Maggiore Hospital, Bologna, Italy.
- 131 Department of Interventional Radiology, Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona, Spain.
- 132 Division of Interventional Radiology, Department of Medical Imaging, London Health Sciences, London, Ontario, Canada.
- 133 Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
- 134 Department of Radiology and Nuclear Medicine, Erasmus MC, Erasmus University, Rotterdam, the Netherlands.
- 135 Department of Surgery, University Hospital Southampton, Southampton, United Kingdom.
- 136 Department of Interventional Radiology, Zhongshan Hospital, Fundan University, Shanghai, China.
- 137 Department of Surgery, IRCCS Ospedale San Raffaele, Milan, Italy.
- 138 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United states.
- 139 Department of Radiology, University Hospital Dr. Josep Trueta, Griona, Spain.
- 140 Institute for Diagnostic and Interventional Radiology and Neuroradiology, Klinikum Saarbruecken, Saarbruecken, Germany.
- 141 Department of Surgery, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
- 142 Department of Radiology, Ottawa hospital, Ottawa, Canada.
- 143 Department of Radiology, University hospital of Linköping, Linköping, Sweden.
- 144 Department of Surgery, HPB Center, Clinic Favoriten, Health Network Vienna, Vienna, Austria.
- 145 Department of Radiology, Miguel Servet University Hospital and University of Zaragoza, Zaragoza, Spain.
- 146 Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
- 147 Department of Surgery, Klinik Hirslanden, Luzern and Zurich, Switzerland.
- 148 Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
- 149 Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
- 150 Department of Digestive and Hepatobiliary/Pancreatic Surgery, Jessa Hospital, Hasselt, Belgium.
- 151 Department of Surgery, Miguel Servet University Hospital Zaragoza, Zaragoza, Spain.
- 152 Department of Surgery, London Health Sciences Centre, London, Ontario, Canada.
- 153 Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
- 154 Department of Surgery, Maastricht University Medical Center+, Maastricht.
- 155 Department of Surgery, Oxford University Hosptials, NHS Foundation trust, Oxford, United Kingdom.
- 156 Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
- 157 Institute for Diagnostic and Interventional Radiology and Neuroradiology, Hospital Saarbrücken, Saarbrücken, Germany.
- 158 Department of General, Visceral, Thoracic and Pediatric Surgery, Hospital Saarbrücken, Saarbrücken, Germany.
- 159 Department of Radiology, Eramse University Hospital - ULB, Brussels, Belgium.
- 160 Department of Radiology, McGill University Health Centre, Montreal, Canada.
- 161 Department of Surgery, Belfast Health and Social Care Trust, Belfast, United Kingdom.
- 162 Department of Radiology, Goethe-University Frankfurt, University Hospital Frankfurt, Germany.
- 163 Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
- 164 Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
- 165 Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
- 166 Department of Radiology, CHU-UCL Namur site Godinne, Namur, Belgium.
- 167 Department of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
- PMID: 39277435
- DOI: 10.1016/j.hpb.2024.07.407
Item in Clipboard
Observational Study
Combined portal and hepatic vein embolisation in perihilar cholangiocarcinoma
Jens Smits et al.
HPB (Oxford).
2024 Dec.
Free article
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doi: 10.1016/j.hpb.2024.07.407.
Epub 2024 Jul 16.
Authors
Jens Smits
1
, Steven Chau
2
, Sinéad James
1
, Remon Korenblik
1
, Madita Tschögl
3
, Pieter Arntz
4
, Jan Bednarsch
5
, Luis Abreu de Carvalho
6
, Olivier Detry
7
, Joris Erdmann
4
, Thomas Gruenberger
3
, Laurens Hermie
8
, Ulf Neumann
9
, Per Sandström
10
, Robert Sutcliffe
11
, Alban Denys
12
, Emmanuel Melloul
13
, Maxime Dewulf
14
, Christiaan van der Leij
15
, Ronald M van Dam
16
; EuroLVD and DRAGON Trials Collaborative
Collaborators
-
EuroLVD and DRAGON Trials Collaborative:
Patrick Chevallier 17 , Stephen Wigmore 18 , Timothy Newhook 19 , Jean-Nicolas Vauthey 19 , Riccardo Memeo 20 , Bobby Vm Dasari 21 , Eva Braunwarth 22 , Luca Aldrighetti 23 , Esteban Cugat Andorrà 24 , Pieter Arntz 25 , Bulent Arslan 26 , Laurens van Baardewijk 27 , Ivan Baclija 28 , Chad Ball 29 , Louise Barbier 30 , Jan Bednarsch 31 , Marc Bemelmans 32 , Clare Bent 33 , Frans van den Bergh 34 , Kevin Billingsley 35 , Christoph Binkert 36 , Bergthor Björnsson 37 , Marieke T de Boer 38 , Reinoud P H Bokkers 39 , Diederick de Boo 40 , Francisco Javier Garcia Borobia 41 , Dries Braat 42 , David Breen 43 , Stefan Breitenstein 44 , Karine Brousseau 45 , Ruther Bruijnen 46 , Philipp Bruners 47 , Christiane Bruns 48 , Alexander Bunck 49 , Mark Burgmans 50 , Alberta Cappelli 51 , Ulrik Carling 52 , Luis Abreu de Carvalho 53 , Charles Cha 54 , Benjamin Chan 55 , Belinda Chand 40 , Thiery Chapelle 56 , Franceso De Cobelli 57 , Laurent Coubeau 58 , Eva Criado 59 , Daniel Croagh 60 , Mathieu D'Hondt 61 , Ronald van Dam 32 , Steven Olde Damink 62 , Rob Davis 63 , Martin Delle 64 , Alban Denys 65 , Fabrice Deprez 66 , Olivier Detry 67 , Maxime Dewulf 62 , Alexandra Dili 68 , Matthew Dixon 69 , Rafael Díaz-Nieto 70 , Joris I Erdmann 71 , Rukshan Fernando 72 , Jaume Codina Font 73 , Suomi Fouraschen 38 , Olivier François 74 , Åsmund A Fretland 75 , Yilian Fundora 76 , Sameer Gadani 77 , Steven Gallinger 78 , Alexandra Geleabert 79 , Laurent Gerard 80 , Josep Guitart Giménez 81 , Paul Gobardhan 82 , Pierre Goffette 83 , Lukasz Filip Grochola 84 , Thomas Gruenberger 85 , Dirk Grünhagen 86 , Felice Guiliante 87 , Fernando Gómez 88 , Jeroen Hagendoorn 89 , John Hammond 90 , Margot Heijmans 91 , Jan Heil 92 , Daniel Heise 31 , Laurens Hermie 93 , Eric Herrero 94 , Gebriel Hess 95 , Sam Heye 96 , Martin Hoffmann 97 , Roberto Iezzi 98 , Farshad Imani 99 , Sinead James 32 , Thomas Jardinet 100 , Kunal Joshi 101 , Elio Jovine 102 , Jennifer Kalil 103 , Paul Karanicolas 104 , Geert Kazemier 25 , Lars Kern 105 , Peter Kingham 106 , Darren Klass 107 , Bas Groot Koerkamp 108 , Otto Kollmar 109 , Remon Korenblik 62 , Choon Kwon 110 , Céline Lambrecht 111 , Sven Lang 112 , Laura-Ann 113 , Wouter Leclercq 91 , Christiaan van der Leij 114 , Richard Lindsay 115 , Santiago Lopez-Ben 116 , Valerio Lucidi 117 , Jordi Navinés López 118 , Andrew Macdonald 119 , David C Madoff 120 , George Markose 121 , Gilbert Maroune 122 , Guillaume Martel 123 , Ernesto Santos Martin 124 , Homoyon Mehrzad 125 , Martijn Meijerink 126 , Emmanuel Melloul 127 , Nouredin Messaoudi 128 , Peter Metrakos 129 , Sachin Modi 43 , Nicola Montanari 130 , Jaume Sampere Moragues 131 , Amol Mujoomdar 132 , Ulf Neumann 31 , Jelmer Oor 133 , Patroklos Pappas 69 , Kay Pieterman 134 , John Primrose 135 , Xudong Qu 136 , Francesca Ratti 137 , Fourat Ridouani 138 , Inne H M Borel Rinkes 89 , Margarida Casellas I Robert 139 , Steffen Ross 140 , Leyo Ruo 141 , Stephen Ryan 142 , Aysun Salik 143 , Per Sandström 37 , Jonas Santol 144 , Luis Sarría 145 , Benedikt Schaarschmidt 146 , Erik Schadde 147 , Marc Schiesser 147 , Moritz Schmelzle 148 , Nico Seeger 105 , Maja Segedi 107 , Matteo Serenari 149 , Gregory Sergeant 150 , Alejandro Serrablo 151 , Sorina Simon 114 , Anton Skaro 152 , Maarten Smits 153 , Jens Smits 154 , Andreas Snitzbauer 92 , Zahir Soonawalla 155 , Ernesto Sparrelid 156 , Elmar Spuentrup 157 , Gregor Stavrou 158 , Robert Sutcliffe 101 , Rutger-Jan Swijnenburg 25 , Ilario Tancredi 159 , Jordan C Tasse 26 , Madita Tschögl 144 , Venkatesha Udupa 155 , David A Valenti 160 , David Vass 161 , Ariadne Lisa van der Velden 114 , Thomas Vogl 162 , Frank Wacker 163 , Xiaoying Wang 164 , Jürgen Weitz 165 , Steven White 90 , Rizky Widyaningsih 113 , Jean-François De Wispelaere 166 , Ijsbrand Zijlstra 167
Affiliations
- 1 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands; GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands.
- 2 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands.
- 3 Department of Surgery, HPB Centre Vienna Health Network, Clinic Favoriten, Wienerbergstraße 13, 1100, Vienna, Austria.
- 4 Department of Surgery, Amsterdam University Medical Centre Location AMC, Meibergdreef 9, 1105, AZ, Amsterdam, The Netherlands.
- 5 Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany.
- 6 Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
- 7 Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, Avenue de l'Hôpital 1, 4000, Liège, Belgium.
- 8 Department of Vascular and Interventional Radiology, Ghent University Hospital, Corneel Heymanslaan 10, 9000, Ghent, Belgium.
- 9 Department of General, Visceral and Transplantation Surgery, Essen University Hospital, Hufelandstraße 55, 45147, Essen, Germany.
- 10 Department of Surgery in Linköping and Biomedical and Clinical Sciences, Linköping University, Universitetssjukhuset, 581 85 Linköping, Sweden.
- 11 Department of Surgery, Queen Elizabeth Hospital Birmingham NHS, Mindelsohn Way, Birmingham, B15 2GW, United Kingdom.
- 12 Department of Radiology and Interventional Radiology, CHUV University of Lausanne, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
- 13 Department of Visceral Surgery, Lausanne University Hospital and University of Lausanne, CHUV, Rue du Bugnon 46, 1011, Lausanne, Switzerland.
- 14 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands. Electronic address: maxime.dewulf@mumc.nl.
- 15 GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands; Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands.
- 16 Department of Surgery, Maastricht University Medical Centre, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands; GROW - School for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229, ER, Maastricht, The Netherlands; Department of General, Visceral and Transplant Surgery, University Hospital Aachen, Pauwelsstraße 30, 52074 Aachen, Germany. Electronic address: r.van.dam@mumc.nl.
- 17 Department of Diagnosis and Interventional Imaging, University Hospital of Nice, France.
- 18 Clinical Surgery, University of Edinburgh & Royal Infirmary of Edinburgh, Scotland.
- 19 Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
- 20 Department of Hepato-Pancreatic-Biliary Surgery, Miulli Hospital, Bari, Italy.
- 21 Department of Hepatobiliary and Pancreatic Surgery, Queen Elizabeth Hospital, Birmingham, United Kingdom.
- 22 Department of Visceral, Transplantation and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria.
- 23 Department of Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milano, Italy.
- 24 Department of Hepato-Pancreato-Biliary Surgery, Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona, Spain, Spain.
- 25 Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, The Netherlands.
- 26 Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, United States.
- 27 Department of Radiology, Maxima Medical Center, Eindhoven, Netherlands.
- 28 department of Radiology, Kaiser Franz Josef Hospital, Vienna, Austria.
- 29 Department of Surgery, Foothills Medical Centre, Calgary, Alberta, Canada.
- 30 Department of Surgery, Auckland District Health Board, Auckland, New Zealand.
- 31 Department of Surgery, University Hospital Aachen, Aachen, Germany.
- 32 Department of Surgery, Maastricht University Medical Center+, Maastricht, Netherlands.
- 33 RBCH, Royal Bournemouth and Christchurch Hospital, Bournemouth, United Kingdom.
- 34 Department of Radiology, Universitair Ziekenhuis Brussel, Brussels, Belgium.
- 35 Department of Surgery, Yale University School of Medicine, New Haven, USA.
- 36 Department of Radiology, Kantonsspital (KSW) Winterthur, Winterthur, Switzerland.
- 37 Department of surgery and Dept of biomedical and clinical sciences, University hospital of Linköping, Linköping, Sweden.
- 38 Hepato-Pancreatico-Biliary Surgery and Liver Transplantation, Department of Surgery, University Medial Center Groningen, Groningen, Netherlands.
- 39 Department of Radiology, University Medical Center Groningen, Groningen, Netherlands.
- 40 Department of Radiology, Monash Health, Clayton, Australia.
- 41 Department of surgery, Parc Tauli Hospital, Sabadell, Spain.
- 42 Department of Surgery, Leids Universitair Medisch Centrum, Leiden, Netherlands.
- 43 Department of Radiology, University Hospital Southampton, Southampton, United Kingdom.
- 44 Department of Surgery, Kantonsspital (KSW) Winterthur, Winterthur, Switzerland.
- 45 Department of Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, Canada.
- 46 Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, the Netherlands.
- 47 Department of Radiology, University Hospital Aachen, Aachen, Germany.
- 48 Department of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine, University Hospital of Cologne, University of Cologne, Cologne, Germany.
- 49 Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
- 50 Department of Radiology, Leids Universitair Medisch Centrum, Leiden, Netherlands.
- 51 Department of Radiology, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
- 52 Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
- 53 Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, Ghent, Belgium.
- 54 Department of Surgery, Yale school of Medicine, New Haven, United States.
- 55 Department of Surgery, Univeristy Hospital Aintree, Liverpool, United Kingdom.
- 56 Department of Hepatobiliary and Transplantation Surgery, Antwerp University Hospital, Edegem, Belgium.
- 57 Department of Radiology, IRCCS Ospedale San Raffale, Milano, Italy.
- 58 Department of Abdominal Surgery and Transplantation, Cliniques Universitaires Saint-Luc, Université catholique de Louvain, Brussels, Belgium.
- 59 Interventional Radiology Unit, UDIAT-Centre Diagnòstic, Hospital Universitario Parc Tauli Sabadell, Medicine Department Universidad Autónoma de Barcelona, Barcelona, Spain.
- 60 Department of Surgery, Monash Health, Clayton, Australia.
- 61 Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, Kortrijk, Belgium.
- 62 Maastricht University Medical Center+, Maastricht, Netherlands.
- 63 Department of Radiology, Aintree University Hospital, Liverpool, United Kingdom.
- 64 Department of Radiology, Karolinska University Hospital, Stockholm, Sweden.
- 65 Department of Radiology and Interventional Radiology, CHUV University of Lausanne, Lausanne, Switzerland.
- 66 Department of Radiology, CHU- UcLouvain-Namur, Yvoir, Belgium.
- 67 Department of Abdominal Surgery and Transplantation, CHU Liege, University of Liege, Belgium.
- 68 Department of Surgery, CHU-UCL Namur site Godine, Namur, Belgium.
- 69 Department of Surgery, Rush University Medical Center, Chicago, USA.
- 70 Department of Surgery, Aintree University Hospital, Liverpool, United Kingdom.
- 71 Department of Surgery, Cancer Center Amsterdam, Amsterdam University Medical Centers, Amsterdan, Netherlands.
- 72 Department of Radiology, Auckland District Health Board, Auckland, New Zealand.
- 73 Department of Interventional Radiology, University Hospital Dr. Josep Trueta, Girona, Spain.
- 74 Department of Medical Imaging, AZ Groeninge, Kortrijk, Belgium.
- 75 Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
- 76 Department of Surgery, Clínic Barcelona, Barcelona, Spain.
- 77 Section of Vascular and Interventional Radiology, Imaging Institute, Cleveland Clinic, Cleveland, Ohio, USA.
- 78 Department of Surgery, University Health Network, Toronto, Canada.
- 79 Department of Radiology, Hospital Parc Taulí de Sabadell, Sabadell, Spain.
- 80 Departement of Radiology, CHU Liege, Belgium.
- 81 Department of Radiology, University Hospital Mútua Terassa, Terassa, Spain.
- 82 Deparment of Surgery, Amphia, Breda, Netherlands.
- 83 Department of Radiology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
- 84 Department of Surgery, Kantonsspital (KSW) Winterthur, Winterthur, Switzerland; Department of Visceral and Thoracic Surgery, Kantonsspital Winterthur, Winterthur, Switzerland.
- 85 Department of Surgery, Kaiser Franz Josef Hospital, Vienna, Austria.
- 86 Department of Surgical Oncology, Erasmus Medical Center, Cancer Institute, Rotterdam, Netherlands.
- 87 Department of Hepato-Biliary Surgery, Catholic University Rome, Rome, Italy.
- 88 Department of Radiology, Clínic de Barcelona, Barcelona, Spain.
- 89 Department of Surgery, UMC Utrecht Cancer Center, Utrecht, Netherlands.
- 90 Department of Surgery, The Newcastle upon Tyne Hospitals, Newcastle, United Kingdom.
- 91 Department of Surgery, Maxima Medical Center, Eindhoven, Netherlands.
- 92 Department of General, Visceral, Transplant and Thoracic Surgery, Goethe-University Frankfurt, University Hospital Frankfurt, Germany.
- 93 Department of Vascular and Interventional Radiology, Ghent University Hospital, Ghent, Belgium.
- 94 Department of Surgery, University Hospital Mútua Terassa, Terassa, Spain.
- 95 Clarunis, University Centre for Gastrointestinal and Liver Diseases, Basel, Switzerland.
- 96 Department of Radiology, Jessa Ziekenhuis, Hasselt, Belgium.
- 97 Department of Radiology, St. Clara hospital, Basel, Switzerland.
- 98 Department of Radiology, Agostino Gemelli University Hospital Rome, Rome, Italy.
- 99 Department of Radiology, Amphia Breda, Netherlands.
- 100 Department of Radiology, Antwerp University Hospital, Edegem, Belgium.
- 101 Department of General Surgery, University Hospital Birmingham, Birmingham, United Kingdom.
- 102 Department of Surgery, Maggiore Hospital, Bologna, Italy.
- 103 McGill University Medical Center, Montreal, Canada.
- 104 Division of General Surgery, Sunnybrook Health Sciences Centre, Canada.
- 105 Department of Visceral and Thoracic Surgery, Kantonsspital Winterthur, Winterthur, Switzerland.
- 106 Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States.
- 107 Department of Surgery, Vancouver General Hospital, Vancouver, Canada.
- 108 Department of Surgery, Erasmus Medisch Centrum, Rotterdam, The Netherlands.
- 109 Department of Surgery, Clarunis University Hospital, Basel, Switzerland.
- 110 Department of Hepato-Pancreato-Biliary/Liver Transplant Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
- 111 Department of Abdominal Surgery and Transplantation, University of Liege, CHU Liege, Liege, Belgium.
- 112 Department of General, Visceral and Transplantation Surgery, Essen University Hospital, Essen, Germany.
- 113 Department of General, Visceral and Thoracic Surgery, Surgical Oncology, Klinikum Saarbruecken, Saarbruecken, Germany.
- 114 Department of Radiology, Maastricht University Medical Center+, Maastricht, Netherlands.
- 115 Department of Radiology, Belfast Health and Social Care Trust, Belfast, United Kingdom.
- 116 Department of Hepato-Biliary and Pancreatic Surgery, University Hospital Dr. Josep Trueta, Griona, Spain.
- 117 Department of Abdominal Surgery, Clinic of Hepato-Biliary Surgery and Liver Transplantation, Erasme University Hospital - ULB, Brussels, Belgium.
- 118 Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona.
- 119 Department of Radiology, Oxford University Hospitals, Oxford, United Kingdom.
- 120 Department of Radiology, Yale school of Medicine, New Haven, United States.
- 121 Department of Radiology, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
- 122 Department of Vascular and Interventional Radiology, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada.
- 123 Department of Surgery, Ottawa hospital, Ottawa, Canada.
- 124 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, USA.
- 125 Deparment of Imaging and Interventional Radiology, Queen Elisabeth Hospital Birmingham, University Hospital Birmingham, Birmingham, United Kingdom.
- 126 Department of Radiology and Nuclear Medicine, Amsterdam University Medical Center VUMC, Amsterdam, Netherlands.
- 127 Department of Visceral Surgery, Lausanne University Hospital and University of Lausanne, CHUV, Lausanne, Switzerland.
- 128 Department of Surgery, Universitair Ziekenhuis Brussel, Brussels, Belgium.
- 129 Department of Surgery, McGill University Hospital, Montreal, Canada.
- 130 Department of Radiology, Maggiore Hospital, Bologna, Italy.
- 131 Department of Interventional Radiology, Hospital Universitari Germans Trias i Pujol de Badalona, Barcelona, Spain.
- 132 Division of Interventional Radiology, Department of Medical Imaging, London Health Sciences, London, Ontario, Canada.
- 133 Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
- 134 Department of Radiology and Nuclear Medicine, Erasmus MC, Erasmus University, Rotterdam, the Netherlands.
- 135 Department of Surgery, University Hospital Southampton, Southampton, United Kingdom.
- 136 Department of Interventional Radiology, Zhongshan Hospital, Fundan University, Shanghai, China.
- 137 Department of Surgery, IRCCS Ospedale San Raffaele, Milan, Italy.
- 138 Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, United states.
- 139 Department of Radiology, University Hospital Dr. Josep Trueta, Griona, Spain.
- 140 Institute for Diagnostic and Interventional Radiology and Neuroradiology, Klinikum Saarbruecken, Saarbruecken, Germany.
- 141 Department of Surgery, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
- 142 Department of Radiology, Ottawa hospital, Ottawa, Canada.
- 143 Department of Radiology, University hospital of Linköping, Linköping, Sweden.
- 144 Department of Surgery, HPB Center, Clinic Favoriten, Health Network Vienna, Vienna, Austria.
- 145 Department of Radiology, Miguel Servet University Hospital and University of Zaragoza, Zaragoza, Spain.
- 146 Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
- 147 Department of Surgery, Klinik Hirslanden, Luzern and Zurich, Switzerland.
- 148 Department of General, Visceral and Transplant Surgery, Hannover Medical School, Hannover, Germany.
- 149 Department of Medical and Surgical Sciences, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
- 150 Department of Digestive and Hepatobiliary/Pancreatic Surgery, Jessa Hospital, Hasselt, Belgium.
- 151 Department of Surgery, Miguel Servet University Hospital Zaragoza, Zaragoza, Spain.
- 152 Department of Surgery, London Health Sciences Centre, London, Ontario, Canada.
- 153 Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
- 154 Department of Surgery, Maastricht University Medical Center+, Maastricht.
- 155 Department of Surgery, Oxford University Hosptials, NHS Foundation trust, Oxford, United Kingdom.
- 156 Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
- 157 Institute for Diagnostic and Interventional Radiology and Neuroradiology, Hospital Saarbrücken, Saarbrücken, Germany.
- 158 Department of General, Visceral, Thoracic and Pediatric Surgery, Hospital Saarbrücken, Saarbrücken, Germany.
- 159 Department of Radiology, Eramse University Hospital - ULB, Brussels, Belgium.
- 160 Department of Radiology, McGill University Health Centre, Montreal, Canada.
- 161 Department of Surgery, Belfast Health and Social Care Trust, Belfast, United Kingdom.
- 162 Department of Radiology, Goethe-University Frankfurt, University Hospital Frankfurt, Germany.
- 163 Department of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany.
- 164 Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
- 165 Department of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
- 166 Department of Radiology, CHU-UCL Namur site Godinne, Namur, Belgium.
- 167 Department of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
- PMID: 39277435
- DOI: 10.1016/j.hpb.2024.07.407
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Abstract
Background: Major hepatectomy in perihilar cholangiocarcinoma (pCCA) patients with a small future liver remnant (FLR) risks posthepatectomy liver failure (PHLF). This study examines combined portal and hepatic vein embolisation (PVE/HVE) to increase preoperative FLR volume and potentially decrease PHLF rates.
Methods: In this retrospective, multicentre, observational study, data was collected from centres affiliated with the DRAGON Trials Collaborative and the EuroLVD registry. The study included pCCA patients who underwent PVE/HVE between July 2016 and January 2023.
Results: Following PVE/HVE, 28% of patients (9/32) experienced complications, with 22% (7/32) necessitating biliary interventions for cholangitis. The median degree of hypertrophy after a median of 16 days was 16% with a kinetic growth rate of 6.8% per week. 69% of patients (22/32) ultimately underwent surgical resection. Cholangitis after PVE/HVE was associated with unresectability. After resection, 55% of patients (12/22) experienced complications, of which 23% (5/22) were Clavien-Dindo grade III or higher. The 90-day mortality after resection was 0%.
Conclusion: PVE/HVE quickly enhances the kinetic growth rate in pCCA patients. Cholangitis impairs chances on resection significantly. Resection after PVE/HVE is associated with low levels of 90-day mortality. The study highlights the potential of PVE/HVE in improving safety and outcomes in pCCA undergoing resection.
Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.
Conflict of interest statement
Conflicts of interest None to declare.
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