Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases
- PMID: 39277536
- DOI: 10.1016/j.numecd.2024.04.005
Modulation of the antioxidant enzyme paraoxonase-1 for protection against cardiovascular diseases
Abstract
Aim: The enzyme paraoxonase 1 (PON1) bound to high-density lipoprotein has received special attention for its protective role against stress-mediated damage and use as a potential regulatory target in atherosclerosis and related vascular diseases.
Data synthesis: We present an overview of the literature on PON1 activity and mRNA levels by investigating its modulation for clinical translations. Specifically, the expression of PON1 and its regulated activity can be modified in different ways with natural substances, drugs, and lifestyle factors thar affect the development of atherosclerosis.
Conclusions: The endothelial contribution of PON1 to overcome differences considering an individual's disease development risk is supported by polymorphism interaction data and the susceptibility to modify PON1 responses in chronic events composed by biological and environmental factors.
Keywords: Antioxidant response; Atherosclerosis; HDL; Inflammation; Lipoperoxidation; Paraoxonase 1.
Copyright © 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Conflict of interest statement
Declaration of competing interest Authors declare that they have no conflict of interest.
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