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Editorial
. 2024 Aug 31;15(4):1987-1992.
doi: 10.21037/jgo-24-323. Epub 2024 Aug 19.

PLK1 and its role in the evolving landscape of KRAS-mutated colorectal cancer

Harry Harvey  1 , Eric Xueyu Chen  1
Affiliations
Editorial

PLK1 and its role in the evolving landscape of KRAS-mutated colorectal cancer

Harry Harvey et al. J Gastrointest Oncol. .
No abstract available

Keywords: Kirsten rat sarcoma virus (KRAS); colorectal cancer (CRC); targeted therapy.

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Conflict of interest statement

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://jgo.amegroups.com/article/view/10.21037/jgo-24-323/coif). E.X.C participated in clinical trials sponsored by Roche, Merck, GSK, BMS, Jassen, Mirati, Novartis, Gilead, and received honoraria from Merck, AstraZeneca, Ipsen, Roche, Eisai, GSK. The other author has no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The RAS pathway is a signal transduction cascade initiated by the activation of RTKs on the cell membrane. These RTKs respond to the binding of growth factors. RAS cycles between an active GTP-bound and an inactive GDP-bound state. Stimulation of RTKs leads to the activation of adaptor proteins like SHP2 and SOS1. These adaptor proteins promote the exchange of GDP for GTP on RAS, thereby activating it. Activated RAS then triggers downstream signaling cascades through the MAPK and PI3K pathways. Key points for potential therapeutic inhibition, discussed in the body of the text, are numbered and highlighted in the legend. RTK, receptor tyrosine kinase; GRB2, growth factor receptor bound protein 2; SHP2, Src-homology 2 domain-containing phosphatase 2; SOS1, son of sevenless homolog 1 ; GDP, guanosine diphosphate; GTP, guanosine triphosphate; GAPs, GTPase activating protein; GEFs, guanine nucleotide exchange factors; KRAS, Kirsten rat sarcoma virus; RAF, rapidly activated fibrosarcoma; MEK, mitogen-activated protein kinase kinase; ERK, extracellular signal-regulated kinase; PI3K, phosphoinositide-3 kinase; AKT, protein kinase B; mTOR, mammalian target of rapamycin; PLK1, Polo like kinase 1; RAS, rat sarcoma virus.
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References

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