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. 2024 Aug 30:11:1448967.
doi: 10.3389/fcvm.2024.1448967. eCollection 2024.

Long-term outcomes of transcatheter atrial septal defect closure: a single-center retrospective study

Lalita Honghiranrueng  1   2 , Supaporn Roymanee  2 , Kanjarut Wongwaitaweewong  2 , Jirayut Jarutach  2 , Rujira Buntharikpornpun  2
Affiliations

Long-term outcomes of transcatheter atrial septal defect closure: a single-center retrospective study

Lalita Honghiranrueng et al. Front Cardiovasc Med. .

Abstract

Background: Transcatheter atrial septal defect (ASD) closure is the primary approach for treating ASD secundum; however, data on long-term outcomes remain limited. This study aimed to elucidate the prevalence of adverse outcomes following transcatheter ASD closure in a diverse population.

Methods: This retrospective cohort study was conducted at the Songklanagarind Hospital and included patients who underwent transcatheter ASD closure between January 2010 and August 2021.

Results: The study included 277 patients who completed follow-up for at least 1 year, with varying ages: <25 years (31%), 25-40 years (19%), 40-60 years (34%), and >60 years (16%). The median follow-up duration was 37 months (interquartile range: 20, 61). The overall mortality rate was 1.8%, and no deaths were attributed to device-related complications. Hospitalization due to heart failure occurred in 0.7% of the cases. Most patients improved or stabilized based on the New York Heart Association functional class. Adverse outcomes included new-onset atrial fibrillation (prevalence: 2.7%) and pulmonary hypertension (prevalence: 0.6%). The resolution of pulmonary hypertension varied among age groups, with 100% resolution in patients <25 years. Multivariate analysis identified male sex, overweight, and history of stroke to be significantly associated with adverse outcomes after transcatheter ASD closure.

Conclusion: Transcatheter ASD closure was safe and effective, with age not being a limiting factor for success. Male sex, being overweight, and a history of stroke were associated with adverse outcomes. These findings contribute to our understanding of the long-term outcomes following ASD closure.

Keywords: atrial fibrillation; atrial septal defect; device closure; patient outcomes; pulmonary hypertension; transcatheter.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
New York heart association functional capacity according to age.
See this image and copyright information in PMC

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References

    1. van der Linde D, Konings EE, Slager MA, Witsenburg M, Helbing WA, Takkenberg JJ, et al. Birth prevalence of congenital heart disease worldwide. J Am Coll Cardiol. (2011) 58:2241–7. 10.1016/j.jacc.2011.08.025 - DOI - PubMed
    1. Sachdeva R. Atrial septal defects. In: Allen HD, Shaddy RE, Penny DJ, Feltes TF, editors. Moss and Adams’ Heart Disease in Infants, Children, and Adolescents Including the fetus and Young Adult. 9th ed. Philadelphia: Lippincott Williams & Wilkins; (2016). p. 739–56.
    1. Baumgartner H, De Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller GP, et al. 2020 ESC guidelines for the management of adult congenital heart disease. Eur Heart J. (2021) 42:563–645. 10.1093/eurheartj/ehaa554 - DOI - PubMed
    1. Humbert M, Kovacs G, Hoeper MM, Badagliacca R, Berger RMF, Brida M, et al. 2022 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension. Eur Respir J. (2023) 61:2200879. 10.1183/13993003.00879-2022 - DOI - PubMed
    1. Brida M, Diller GP, Kempny A, Drakopoulou M, Shore D, Gatzoulis MA, et al. Atrial septal defect closure in adulthood is associated with normal survival in the mid to longer term. Heart. (2019) 105:1014–9. 10.1136/heartjnl-2018-314380 - DOI - PubMed

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