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. 2024 Aug 30:11:1448967.
doi: 10.3389/fcvm.2024.1448967. eCollection 2024.

Long-term outcomes of transcatheter atrial septal defect closure: a single-center retrospective study

Lalita Honghiranrueng  1   2 , Supaporn Roymanee  2 , Kanjarut Wongwaitaweewong  2 , Jirayut Jarutach  2 , Rujira Buntharikpornpun  2
Affiliations

Long-term outcomes of transcatheter atrial septal defect closure: a single-center retrospective study

Lalita Honghiranrueng et al. Front Cardiovasc Med. .

Abstract

Background: Transcatheter atrial septal defect (ASD) closure is the primary approach for treating ASD secundum; however, data on long-term outcomes remain limited. This study aimed to elucidate the prevalence of adverse outcomes following transcatheter ASD closure in a diverse population.

Methods: This retrospective cohort study was conducted at the Songklanagarind Hospital and included patients who underwent transcatheter ASD closure between January 2010 and August 2021.

Results: The study included 277 patients who completed follow-up for at least 1 year, with varying ages: <25 years (31%), 25-40 years (19%), 40-60 years (34%), and >60 years (16%). The median follow-up duration was 37 months (interquartile range: 20, 61). The overall mortality rate was 1.8%, and no deaths were attributed to device-related complications. Hospitalization due to heart failure occurred in 0.7% of the cases. Most patients improved or stabilized based on the New York Heart Association functional class. Adverse outcomes included new-onset atrial fibrillation (prevalence: 2.7%) and pulmonary hypertension (prevalence: 0.6%). The resolution of pulmonary hypertension varied among age groups, with 100% resolution in patients <25 years. Multivariate analysis identified male sex, overweight, and history of stroke to be significantly associated with adverse outcomes after transcatheter ASD closure.

Conclusion: Transcatheter ASD closure was safe and effective, with age not being a limiting factor for success. Male sex, being overweight, and a history of stroke were associated with adverse outcomes. These findings contribute to our understanding of the long-term outcomes following ASD closure.

Keywords: atrial fibrillation; atrial septal defect; device closure; patient outcomes; pulmonary hypertension; transcatheter.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
New York heart association functional capacity according to age.
See this image and copyright information in PMC

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