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Meta-Analysis
. 2024 Aug;4(2):e951.
doi: 10.52225/narra.v4i2.951. Epub 2024 Aug 10.

Association between triglyceride-glucose index and hypertension: A systematic review and meta-analysis

Antonia A Lukito  1   2 , William Kamarullah  3 , Ian Huang  4   5 , Raymond Pranata  1   2
Affiliations
Meta-Analysis

Association between triglyceride-glucose index and hypertension: A systematic review and meta-analysis

Antonia A Lukito et al. Narra J. 2024 Aug.

Abstract

The triglyceride-glucose (TyG) index is a simple and reliable indicator of insulin resistance, which is an important contributor to the development of hypertension. The aim of this meta-analysis was to determine the dose-response association between the TyG index and the incidence of hypertension. An extensive search was conducted through several databases, including PubMed, EMBASE, ScienceDirect, and Scopus, until June 1, 2024. The TyG index was used as the exposure, and the incidence of hypertension was measured throughout the TyG index intervals. The effect estimates were presented as odds ratios (OR) in both the unadjusted and adjusted models. Adjusted OR were carried out from all included studies to eliminate the possibility of confounding factors being involved in the incidence of hypertension. A total of 108.936 participants (mean age: 48.2 years old, male: 47%, mean body mass index: 23.9 kg/m2) from 14 observational studies were included. The TyG index in the most eminent category was related to a higher risk of hypertension in both unadjusted (OR: 2.59, 95%CI: 2.03-3.31, p<0.001; I2: 97.1%, p<0.001) and adjusted model (OR: 1.74, 95%CI: 1.39-2.19, p<0.001; I2: 92.2%, p<0.001). The dose-response meta-analysis for the adjusted OR showed that the linear association analysis was not significant per 0.1 increase in the TyG index. The dose-response curve became increasingly steeper at the TyG index above 8.5. In conclusion, the TyG index was shown to be strongly linked with hypertension in a non-linear dose-response manner.

Keywords: Blood pressure; hypertension; insulin resistance; lipid; triglyceride-glucose index.

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Conflict of interest statement

All the authors declare that there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
PRISMA flowchart.
Figure 2.
Figure 2.
The triglyceride-glucose index and hypertension, with highest vs lowest categories in unadjusted model (A) and adjusted model (B).
Figure 3.
Figure 3.
A dose-response meta-analysis of the triglyceride-glucose (TyG) index and the incidence of hypertension. The TyG index is associated with a higher risk of hypertension, as indicated by an adjusted odds ratio (AOR) (solid line) and a 95% confidence interval (long dashed lines).
See this image and copyright information in PMC

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