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Clinical Trial
. 1985 Sep 7;291(6496):648-50.
doi: 10.1136/bmj.291.6496.648.

Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole

I Ahmadsyah, A Salim
Clinical Trial

Treatment of tetanus: an open study to compare the efficacy of procaine penicillin and metronidazole

I Ahmadsyah et al. Br Med J (Clin Res Ed). .

Abstract

A prospective, open, non-randomised clinical trial was carried out to compare the efficacy of procaine penicillin with metronidazole in the treatment of moderate tetanus among 173 patients. Patients in the metronidazole group had a significantly lower mortality rate, a shorter stay in hospital, and an improved response to treatment. These results establish the value of antimicrobial treatment in the management of tetanus and show that metronidazole is more efficacious than penicillin in this respect.

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References

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    1. Lancet. 1967 Jun 3;1(7501):1216-7 - PubMed

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