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. 2024 Aug 24:37:e02067.
doi: 10.1016/j.idcr.2024.e02067. eCollection 2024.

Epidemiological and clinical characteristics of nontuberculous mycobacterial infections: A retrospective female cohort study in an Italian population

Andrea Marino  1 , Michele Salvatore Paternò Raddusa  2 , Maria Gussio  1 , Giuseppe Sangiorgio  3 , Vittoria Moscatt  1 , Alessandro Libra  4 , Serena Spampinato  2 , Dafne Bongiorno  3 , Bruno Cacopardo  1 , Giuseppe Nunnari  1
Affiliations

Epidemiological and clinical characteristics of nontuberculous mycobacterial infections: A retrospective female cohort study in an Italian population

Andrea Marino et al. IDCases. .

Abstract

Objectives: This study aims to assess the characteristics and treatment outcomes of patients diagnosed with non-tuberculous mycobacteria (NTM) diseases at the Infectious Diseases Unit of ARNAS Garibaldi Hospital in Catania, Italy, focusing on demographics, clinical features, and treatment effectiveness.

Methods: We conducted a retrospective observational study of 10 patients diagnosed with NTM diseases between 2019 and 2021. Data was collected from electronic medical records, including demographic information, comorbidities, treatment modalities, and outcomes. The study utilized descriptive statistics to analyze continuous and categorical variables. Treatment regimens were based on individual patient needs, incorporating a combination of antibiotics.

Results: The median age of the patients was 55.44 years, all female, predominantly suffering from pulmonary NTM diseases. Mycobacterium intracellulare was the most common pathogen. Common comorbidities included COPD, bronchiectasis, GERD, and hypovitaminosis D. Patients showed symptoms like fever, cough, and asthenia. The treatment regimens were diverse, with macrolides, rifampicin, and ethambutol forming the core. Adverse effects were noted in 40 % of patients, including gastrointestinal and neurological disorders. All patients achieved microbiological cure, with 60 % showing clinical improvement and 36 % radiological improvement.

Conclusion: The study highlights the complexity of diagnosing and treating NTM diseases, emphasizing the need for personalized treatment plans and vigilant monitoring of adverse effects. Despite achieving microbiological cure, challenges remain in achieving complete clinical and radiological resolution. Further research is needed to enhance the understanding and management of NTM diseases, particularly in diverse populations.

Keywords: Mycobacterial pulmonary infections; Mycobacterium chelonae; Mycobacterium intracellulare; NTM infections; Nontuberculous mycobacteria.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Antibiotic treatment regimen of patient 3 with M. chelonae infection; x-axis reports duration in months.
Fig. 2
Fig. 2
Antibiotic treatment regimen of patient 8 with M. chelonae infection; x-axis reports duration in months.
See this image and copyright information in PMC

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