Comparative Study
doi: 10.1016/0305-0491(85)90381-5.
On the loss of uricolytic activity during primate evolution--I. Silencing of urate oxidase in a hominoid ancestor
- PMID: 3928241
- DOI: 10.1016/0305-0491(85)90381-5
Item in Clipboard
Comparative Study
On the loss of uricolytic activity during primate evolution--I. Silencing of urate oxidase in a hominoid ancestor
Comp Biochem Physiol B.
1985.
Abstract
Urate oxidase activity is not detectable in liver homogenates from the gibbon, orangutan, chimpanzee, gorilla and human. Liver homogenates from five genera of Old World and two genera of New World monkeys have easily detectable levels of urate oxidase activity. There is no evidence for extant detectable intermediate steps in the loss of urate oxidase activity in the hominoids. Urate oxidase activity from Old World and New World monkeys is stable, a simple observation which debunks a long-standing myth. Urate oxidase activity was silenced in an ancestor to the five living genera of hominoids after divergence from the Old World monkeys.
Similar articles
-
Two independent mutational events in the loss of urate oxidase during hominoid evolution.J Mol Evol. 1992 Jan;34(1):78-84. doi: 10.1007/BF00163854. J Mol Evol. 1992. PMID: 1556746
-
The phylogeny of the hominoid primates, as indicated by DNA-DNA hybridization.J Mol Evol. 1984;20(1):2-15. doi: 10.1007/BF02101980. J Mol Evol. 1984. PMID: 6429338 Review.
-
DNA hybridization evidence of hominoid phylogeny: results from an expanded data set.J Mol Evol. 1987;26(1-2):99-121. doi: 10.1007/BF02111285. J Mol Evol. 1987. PMID: 3125341
-
Immunoglobulin CH gene family in hominoids and its evolutionary history.Genomics. 1992 May;13(1):194-200. doi: 10.1016/0888-7543(92)90220-m. Genomics. 1992. PMID: 1577482
-
Chromosomal phylogeny of the primates.Annu Rev Genet. 1978;12:289-328. doi: 10.1146/annurev.ge.12.120178.001445. Annu Rev Genet. 1978. PMID: 106768 Review. No abstract available.
Cited by
-
Atavistic strategy for the treatment of hyperuricemia via ionizable liposomal mRNA.Nat Commun. 2024 Jul 31;15(1):6463. doi: 10.1038/s41467-024-50752-9. Nat Commun. 2024. PMID: 39085241 Free PMC article.
-
Rat urate oxidase produced by recombinant baculovirus expression: formation of peroxisome crystalloid core-like structures.Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4908-12. doi: 10.1073/pnas.89.11.4908. Proc Natl Acad Sci U S A. 1992. PMID: 1594592 Free PMC article.
-
A fly GWAS for purine metabolites identifies human FAM214 homolog medusa, which acts in a conserved manner to enhance hyperuricemia-driven pathologies by modulating purine metabolism and the inflammatory response.Geroscience. 2022 Aug;44(4):2195-2211. doi: 10.1007/s11357-022-00557-9. Epub 2022 Apr 6. Geroscience. 2022. PMID: 35381951 Free PMC article.
-
Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog.PLoS Genet. 2008 Nov;4(11):e1000246. doi: 10.1371/journal.pgen.1000246. Epub 2008 Nov 7. PLoS Genet. 2008. PMID: 18989453 Free PMC article.
-
Diurnal rhythms of urine volume and electrolyte excretion in healthy young men under differing intensities of daytime light exposure.Sci Rep. 2021 Jun 23;11(1):13097. doi: 10.1038/s41598-021-92595-0. Sci Rep. 2021. PMID: 34162962 Free PMC article. Clinical Trial.